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徐 斌 副教授
2017-04-07 15:21   审核人:



一、个人简介

徐斌,副教授、博士生导师,环境卫生教研室。

 

二、教育经历

1997-2002年:中国医科大学 预防医学 本科

2002-2005年:中国医科大学 劳动卫生与环境卫生学 硕士

2007-2010年:中国医科大学 劳动卫生与环境卫生学 博士

 

三、工作经历

2005-2007年:中国医科大学 公共卫生学院 环境卫生教研室 助教

2007-2012年:中国医科大学 公共卫生学院 环境卫生教研室 讲师

2012-至今:  中国医科大学 公共卫生学院 环境卫生教研室 副教授

2015.1-2015.12:美国杜克大学  Multidisciplinary Neuroprotection Laboratories    访问学者

 

四、研究方向

环境神经毒理学。

 

五、 主持课题情况

1. 国家自然科学基金:Alpha-synuclein与Rab3a蛋白的相互作用及其对锰干扰氨基酸类神经递质释放的影响。2014-2017年;70万元。

2. 辽宁省高等学校杰出青年学者成长计划. 2014-2017年;12万元。

3. 国家自然科学基金:α-synuclein可溶性寡聚体在锰致神经细胞损伤中的作用及其形成机制。2012-2014年;22万元。

 

六、文章发表情况

1.Wang C, Xu B*, Song QF, Deng Y, Liu W, Xu ZF. Manganese exposure disrupts SNARE protein complex-mediated vesicle fusion in primary cultured neurons. Environ Toxicol. 2016. doi: 10.1002/tox.22272.

2.Xu B*, Liu W, Deng Y, Yang TY, Feng S, Xu ZF.Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. PLoS One. 2015, 10(3): e0119205.

3.Xu B*, Jin CH, Deng Y, Liu W, Yang TY, Feng S, Xu ZF. Alpha-Synuclein Oligomerization in Manganese-Induced Nerve Cell Injury in Brain Slices: A Role of NO-Mediated S-Nitrosylation of Protein Disulfide Isomerase. 2014, 50(3): 1098-1110.

4.Deng Y*, Jiao C, Mi C, Xu B, Li Y, Wang F, Liu W, Xu Z. Melatonin Inhibits Manganese-Induced Motor Dysfunction and Neuronal Loss in Mice: Involvement of Oxidative Stress and Dopaminergic Neurodegeneration. Molecular Neurobiology. 2014, 49(1): 399-412.

5.Xu B*, Wang F, Wu SW, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Alpha-Synuclein is Involved in Manganese-Induced ER Stress via PERK Signal Pathway in Organotypic Brain Slice Cultures. Mol Neurobiol. 2014, 49(1): 399-412.

6.Liu W, Xu Z*, Yang T, Deng Y, Xu B, Feng S, Li Y. The protective role of tea polyphenols against methylmercury-induced neurotoxic effects in rat cerebral cortex via inhibition of oxidative stress. Free Radic Res. 2014, 12:1-15.

7.Liu W, Xu Z*, Deng Y, Xu B, Yang H, Wei Y, Feng S. Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols. Environ Toxicol. 2014, 29(3): 269-283.

8.Deng Y, Xu Z*, Xu B, Liu W, Wei Y, Li Y, Feng S, Yang T.Exploring cross-talk between oxidative damage and excitotoxicity and the effects of riluzole in the rat cortex after exposure to methylmercury.Neurotox Res. 2014, 26(1):40-51.

9.Feng S, Xu Z*, Liu W, Li Y, Deng Y, Xu B. Preventive effects of dextromethorphan on methylmercury-induced glutamate dyshomeostasis and oxidative damage in rat cerebral cortex. Biol Trace Elem Res. 2014, 159(1-3):332-345.

10.Xu B*, Shan M, Wang F, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures. Toxicol Lett. 2013, 222(3):239-246.

11.Xu B*, Wu SW, Lu CW, Deng Y, Liu W, Wei YG, Yang TY, Xu ZF. Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures. Toxicology. 2013, 305:71-78.

12.Xu B, Xu Z*, Deng Y, Liu W, Yang H, Wei YG. MK-801 protects against intracellular Ca(2+) overloading and improves N-methyl-D-aspartate receptor expression in cerebral cortex of methylmercury-poisoned rats. J Mol Neurosci. 2013, 49(1):162-171.

13.Liu W, Xu Z*, Deng Y, Xu B, Wei Y, Yang T.Protective effects of memantine against methylmercury-induced glutamate dyshomeostasis and oxidative stress in rat cerebral cortex. Neurotox Res. 2013, 24(3): 320-337.

14.Deng Y, Xu ZF*, Liu W, Xu B, Yang HB, Wei YG.Riluzole-triggered GSH synthesis via activation of glutamate transporters to antagonize methylmercury-induced oxidative stress in rat cerebral cortex. Oxid Med Cell Longev. 2012, 2012: 534705.

15.Deng Y, Xu Z*, Xu B, Xu D, Tian Y, Feng W.The protective effects of riluzole on manganese-induced disruption of glutamate transporters and glutamine synthetase in the cultured astrocytes. Biol Trace Elem Res. 2012, 148(2):242-249.

16.Xu B, Xu ZF*, Deng Y, Liu W, Yang HB, Wei YG. Protective effects of mk-801 on methylmercury-induced neuronal injury in rat cerebral cortex: Involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology. 2012, 300(3): 112-120.

17.Yang H, Xu Z*, Liu W, Wei Y, Deng Y, Xu B. Effect of grape seed proanthocyanidin extracts on methylmercury-induced neurotoxicity in rats. Biol Trace Elem Res. 2012, 147(1-3):156-164.

18.Deng Y, Xu Z*, Liu W, Yang H, Xu B, Wei Y. Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol Trace Elem Res. 2012, 146(2):213-223.

19.Deng Y, Xu D, Xu B, Xu Z*, Tian Y, Feng W, Liu W, Yang H.G0/G1 phase arrest and apoptosis induced by manganese chloride on cultured rat astrocytes and protective effects of riluzole. Biol Trace Elem Res. 2011, 144(1-3):832-842.

20.Yang H, Xu Z*, Liu W, Deng Y, Xu B. The protective role of procyanidins and lycopene against mercuric chloride renal damage in rats. Biomed Environ Sci. 2011, 24(5):550-559.

21.Liu W, Xu Z*, Yang H, Deng Y, Xu B, Wei Y. The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury. Biol Trace Elem Res. 2011, 143(3):1651-1665.

22.Xu B, Xu ZF*, Deng Y. Protective Effects of MK-801 on Manganese-Induced Glutamate Metabolism Disorder in rat striatum. Exp Toxicol Pathol. 2010, 62(4): 381-390.

23.Xu B, Xu ZF*, Deng Y. Manganese exposure alters the expression of N-methyl-d-aspartate receptor subunit mRNAs and proteins in rat striatum. J Biochem Mol Toxicol. 2010, 24(1): 1-9.

24.Xu B, Xu ZF*, Deng Y, Yang JH. Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol. 2010, 62(1): 27-34.

25.Xu Z*, Jia K, Xu B, He A, Li J, Deng Y, Zhang F.Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats. Toxicol Ind Health. 2010, 26(1):55-60.

26.Deng Y, Xu Z*, Xu B, Tian Y, Xin X, Deng X, Gao J.The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats.Brain Res. 2009, 1289:106-117.

27.Xu B, Xu ZF*, Deng Y. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology. 2009, 30(6): 941-949.

28.Deng Y, Xu Z*, Xu B, Tian Y, Deng X, Xin X, Gao J. Excitotoxicity in rat's brain induced by exposure of manganese and neuroprotective effects of pinacidil and nimodipine. Biol Trace Elem Res. 2009, 131(2):143-153.

 

七、研究生培养情况

硕士招生:2014年开始,共招收4人。

博士招生:2016年开始,共招收2人。


  : bxu10@cmu.edu.cn


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