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邓 宇 副教授
2017-04-07 15:33   审核人:

一、个人简介

邓宇,副教授、博士生导师,环境卫生学教研室,辽宁省“百千万”人才工程万人层次人选。

 

二、教育经历

2000-2005年:沈阳医学院 预防医学专业 本科

2005-2010年:中国医科大学 公共卫生学院 硕博连读

 

三、工作经历(包括博士后及出国进修经历)

2010-2012年:中国医科大学 环境卫生学教研室 讲师

2012-至今: 中国医科大学 环境卫生学教研室 副教授

 

四、研究方向

环境神经毒理学。

 

五、主持课题情况

1. 国家自然科学基金:Nrf2诱导EAATs和Xc-系统调控GSH合成在锰神经毒性中的作用及机制。2014-2016年;23万元。

2. 教育部高等学校博士学科点专项科研基金新教师类:锰致大鼠神经毒性及iPS细胞分化成的多巴胺能神经元移植对其的修复作用。2012-2014年;4万元。

 

六、文章发表情况

1. Deng Y*, Jiao CC, Mi C, Xu B, Li YH, Wang F, Liu W, Xu ZF. Melatonin Inhibits Manganese-Induced Motor Dysfunction and Neuronal Loss in Mice: Involvement of Oxidative Stress and Dopaminergic Neurodegeneration. Mol Neurobiol. 2014; DOI: 10.1007/s12035-014-8789-3

2. Deng Y*, Zhu JY, Mi C, Xu B, Jiao CC, Li YH, Xu DH, Liu W, Xu ZF. Melatonin Antagonizes Mn-induced Oxidative Injury through the Activation of Keap1-Nrf2-ARE Signaling Pathway in the Striatum of Mice. Neurotox Res. 2014; DOI: 10.1007/s12640-014-9489-5

3. Deng Y, Xu ZF*, Xu B, Liu W, Feng S, Yang TY. Antioxidative effects of schidandrin B and green tea polyphenols against mercuric chloride-induced hepatotoxicity in rats. J Environ Pathol Toxicol Oncol. 2014; Accepted

4. Deng Y, Xu ZF*, Xu B, Liu W, Wei YG, Li YH, Feng S, Yang TY. Exploring cross-talk between oxidative damage and excitotoxicity and the effects of riluzole in the rat cortex after exposure to methylmercury. Neurotox Res. 2014; 26(1):40-51.

5. Deng Y, Xu ZF*, Liu W, Xu B, Yang HB, Wei YG. Riluzole-triggered GSH synthesis via activation of glutamate transporters to antagonize methylmercury-induced oxidative stress in rat cerebral cortex. Oxid Med Cell Longev. 2012; 2012:534705.

6. Deng Y, Xu ZF*, Xu B, Xu D, Tian YW, Feng WY. The protective effects of riluzole on manganese-induced disruption of glutamate transporters and glutamine synthetase in the cultured astrocytes. Biol Trace Elem Res. 2012; 148(2):242-249.

7. Deng Y, Xu ZF*, Liu W, Yang HB, Xu B, Wei YG. Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol Trace Elem Res. 2012; 146:213-223.

8. Deng Y, Xu DH, Xu B, Xu ZF*, Tian YW, Feng WY, Liu W, Yang HB. G0/G1 phase arrest and apoptosis induced by manganese chloride on cultured rat astrocytes and protective effects of riluzole. Biol Trace Elem Res. 2011; 144:832-842.

9. Deng Y, Xu ZF*, Xu B, Tian YW, Xin X, Deng XQ, Gao J. The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats. Brain Res. 2009; 1289:106-117.

10. Deng Y, Xu ZF*, Xu B, Tian YW, Deng XQ, Xin X, Gao J. Excitotoxicity in rat's brain induced by exposure of manganese and neuroprotective effects of pinacidil and nimodipine. Biol Trace Elem Res. 2009; 131: 143-153.

11. Xu B*, Jin CH, Deng Y, Liu W, Yang TY, Feng S, Xu ZF. Alpha-Synuclein Oligomerization in Manganese-Induced Nerve Cell Injury in Brain Slices: A Role of NO-Mediated S-Nitrosylation of Protein Disulfide Isomerase. Mol Neurobiol. 2014; DOI: 10.1007/s12035-014-8711-z

12. Feng S, Xu ZF*, Liu W, Li YH, Deng Y, Xu B. Preventive effects of dextromethorphan on methylmercury-induced glutamate dyshomeostasis and oxidative damage in rat cerebral cortex. Biol Trace Elem Res. 2014; 159(1-3): 332-345.

13. Xu B*, Wang F, Wu SW, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Mol Neurobiol. 2014; 49(1): 399-412.

14. Xu B*, Shan M, Wang F, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures. Toxicol Lett. 2013; 222: 239-246.

15. Xu B*, Wu SW, Lu CW, Deng Y, Liu W, Wei YG, Yang TY, Xu ZF. Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures. Toxicology. 2013; 305:71-78.

16. Xu B, Xu ZF*, Deng Y, Liu W, Yang HB, Wei YG. MK-801 protects against intracellular Ca(2+) overloading and improves N-methyl-D-aspartate receptor expression in cerebral cortex of methylmercury-poisoned rats. J Mol Neurosci. 2013; 49:162-171.

17. Liu W, Xu ZF*, Deng Y, Xu B, Wei Y, Yang T. Protective effects of memantine against methylmercury-induced glutamate dyshomeostasis and oxidative stress in rat cerebral cortex. Neurotox Res. 2013; 24:320-337.

18. Xu B, Xu ZF*, Deng Y, Liu W, Yang HB, Wei YG. Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology. 2012; 300:112-120.

19. Liu W, Xu ZF*, Deng Y, Xu B, Yang HB, Wei YG, Feng S. Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols. Environ Toxicol. 2012; DOI 10.1002/tox.21755.

20. Yang HB, Xu ZF*, Liu W, Wei YG, Deng Y, Xu B. Effect of grape seed proanthocyanidin extracts on methylmercury-induced neurotoxicity in rats. Biol Trace Elem Res. 2012; 147:156-164.

21. Liu W, Xu ZF*, Yang H, Deng Y, Xu B, Wei YG. The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury. Biol Trace Elem Res. 2011; 143:1651-1665.

22. Yang HB, Xu ZF*, Liu W, Deng Y, Xu B. The protective role of procyanidins and lycopene against mercuric chloride renal damage in rats. Biomed Environ Sci. 2011; 24:550-559.

23. Xu B, Xu ZF*, Deng Y. Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum. J Biochem Mol Toxicol. 2010; 24:1-9.

24. Xu B, Xu ZF*, Deng Y. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Exp Toxicol Pathol. 2010; 62:381-390.

25. Xu B, Xu ZF*, Deng Y, Yang JH. Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol. 2010; 62:27-34.

26. Xu ZF*, Jia K, Xu B, He AN, Li J, Deng Y, Zhang FL. Effects of MK- 801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats. Toxicol Ind Health. 2010; 26:55-60.

27. Xu B, Xu ZF*, Deng Y. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. NeuroToxicology. 2009; 30:941-949.

28. Zhang FL, Xu ZF*, Gao J, Xu B, Deng Y. In vitro Effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain. Environ Toxicol Pharmacol. 2008; 26:232-236.

 

七、研究生培养情况

硕士招生:2014年开始,共招收1人,学术学位。


: dengyu.cmu@163.com


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