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贺 淼 副教授
2017-04-07 15:36   审核人:

一、个人简介

贺淼,副教授,环境教研室,辽宁省“百千万人才工程”万层次

 

二、教育经历

2000-2005年:中国医科大学 预防医学 本科

2005-2010年:中国医科大学 劳动卫生与环境卫生学 硕博连读

 

三、工作经历(包括博士后及出国进修经历)

2008-2011年:日本大分县立看护科学大学 生体反应学 共同研究员

2011-2013年:日本大分县立看护科学大学 生体反应学 博士后

2013-2015年:中国医科大学 公共卫生学院 环境与慢性疾病研究中心 讲师

2015-2016年:中国医科大学 公共卫生学院 环境与慢性疾病研究中心 副教授

2016年至今:中国医科大学 公共卫生学院 环境教研室 副教授

 

四、研究方向

1. 环境污染物对呼吸系统损伤及其机制研究;

2. 环境污染损害鉴定评估;

3. 室内空气污染健康评价研究。 

 

五、主持课题情况

1. 沈阳市自然科学基金:鱼腥草对PM2.5所致肺部炎症的拮抗作用及其机制的研究。2017.1-2018.12;5万元。

2. 辽宁省自然科学基金:沈阳地区室内空气环境健康评价研究。2017.7-2019.6;5万元。

3. 国家自然科学基金:我国北方城市空气污染中PM2.5对支气管哮喘的影响及其机制的研究。2014.1-2016.12;23万元。4. 日本文部省科学研究基金:应用霉菌标品探明黄沙颗粒物对杉树花粉症致敏作用机制的实验研究。2011.4-2013.3;338万日元。

 

六、文章发表情况(*通讯作者) 

1. He M*, Ichinose T*, Yoshida Y, Arashidani K, Yoshida S, Takano H, Sun G, Shibamoto T. Urban PM2.5 exacerbates allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway. Sci Rep, 2017; 7(1):11027.

2. He M*, Ichinose T*, Yoshida S, Ito T, He C, Yoshida Y, Arashidani K, Takano H, Sun G, Shibamoto T. PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells. J Appl Toxicol, 2017; 37(10):1203-1218.

3. He M*, Ichinose T*, Yoshida S, Shiba F, Arashidani K, Takano H, Sun G, Shibamoto T. Differences in allergic inflammatory responses in murine lungs: Comparison of PM2.5 and coarse PM collected during the hazy events in a Chinese city. Inhal Toxicol, 2016;28(14):706-718.

4. He M*, Ichinose T*, Kobayashi M, Arashidani K, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T. Differences in allergic inflammatory responses between urban PM2.5 and fine particle derived from desert-dust in murine lungs. Toxicol Appl Pharmacol. 2016; 297: 41-55.

5. He M*, Ichinose T*, Song Y, Yoshida Y, Bekki K, Arashidani K,  Yoshida S, Nishikawa M, Takano H, Shibamoto T, Sun G. Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. Toxicol Appl Pharmacol. 2016; 296: 61-72.

6. He M*, Ichinose T*, Liu B, Song Y, Yoshida Y, Kobayashi F, Maki T, Yoshida S, Nishikawa M, Takano H, Sun G. Silica-carrying particulate matter enhances Bjerkandera adusta-induced murine lung eosinophilia. Environ Toxicol. 2016; 31(1): 93-105.

7. He M*, Ichinose T, Yoshida S, Takano H, Nishikawa M, Shibamoto T, Sun G. Exposure to bisphenol A enhanced lung eosinophilia in adult male mice. Allergy Asthma Clin Immunol. 2016; 12: 16.

8. He M*, Ichinose T*, Ren Y, Song Y, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G.PM2.5-rich dust collected from the air in Fukuoka, Kyushu, Japan, can exacerbate murine lung eosinophilia. Inhal Toxicol. 2015; 27(6): 287-299.

9. He M*, Ichinose T, Song Y, Yoshida Y, Kobayashi F, Maki T, Yoshida S, Takano H, Shibamoto T, Sun G. The Role of Toll-Like Receptors and Myeloid Differentiation Factor 88 in Bjerkandera adusta-Induced Lung Inflammation. Int Arch Allergy Immunol. 2015; 168(2): 96-106.

10. He M*, Ichinose T*, Song Y, Yoshida Y, Arashidani K, Yoshida S, Liu B, Nishikawa M, Takano H, Sun G. Effects of two Asian sand dusts transported from the dust source regions of Inner Mongolia and northeast China on murine lung eosinophilia. Toxicol Appl Pharmacol. 2013; 272(3): 647-655.

11. He M, Ichinose T, Yoshida S, Takano H, Nishikawa M, Sun G, Shibamoto T*.Induction of immune tolerance and reduction of aggravated lung eosinophilia by co-exposure to Asian sand dust and ovalbumin for 14 weeks in mice. Allergy Asthma Clin Immunol. 2013; 9(1): 19.

12. He M, Inoue K*, Yoshida S, Tanaka M, Takano H, Sun G, Ichinose T. Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. Immunopharmacol Immunotoxicol. 2013; 35(3): 390-395.

13. He M, Ichinose T, Yoshida S, Yamamoto S, Inoue K, Takano H, Yanagisawa R, Nishikawa M, Mori I, Sun G, Shibamoto T*. Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumoniae. Toxicol Appl Pharmacol. 2012; 258(2): 237-247.

14. He M, Ichinose T, Yoshida S, Takano H, Nishikawa M, Mori I, Sun G, Shibamoto T*. Aggravating effects of Asian sand dust on lung eosinophilia in mice immunized beforehand by ovalbumin. Inhal Toxicol. 2012; 24(11): 751-761.

15. He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G, Shibamoto T*. Airborne Asian sand dust enhances murine lung eosinophilia. Inhal Toxicol. 2010; 22(12): 1012-1025.

16. He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G, Shibamoto T*. Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia. Inhal Toxicol. 2010; 22(9): 709-718.

17. He C, Song Y, Ichinose T, He M, Morita K, Wang D, Kanazawa T, Yoshida Y. Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced-immunosuppressive effects in mouse splenocytes. J Appl Toxicol. 2018 Apr;38(4):471-479.

18. Yu N, Sun YT, Su XM, He M, Dai B, Kang J. Eucalyptol Protects Lungs against Bacterial Invasion through Attenuating Ciliated Cell Damage and Suppressing MUC5AC Expression. J Cell Physiol. 2017 Dec 7. doi: 10.1002/jcp.26359.

J Cell Physiol. 2017 Dec 7. doi: 10.1002/jcp.26359.

19. Yu N, Sun YT, Su XM, He M, Dai B, Kang J*. Melatonin attenuates TGFβ1-induced epithelial-mesenchymal transition in lung alveolar epithelial cells. Mol Med Rep. 2016;14(6):5567-5572.

Yoshida S*, Ichinose T, Arashidani K, He M, Takano H, Shibamoto T. Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring. Int J Environ Res Public Health, 2016;13(11): pii: E1173.

21. Song Y, Ichinose T, He M, He C, Morita K, Yoshida Y*. Lipopolysaccharide attached to urban particulate matter 10 suppresses immune responses in splenocytes while particulate matter itself activates NF-kappa B. Toxicol Res. 2016; 5(5): 1445-1452.

22. Bekki K, Ito T, Yoshida Y, He C, Arashidani K, He M, Sun G, Zeng Y, Sone H, Kunugita N, Ichinose T. PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways. Environ Toxicol Pharmacol. 2016; 45: 362-369.

23. Liu B, Ichinose T, He M, Kobayashi F, Maki T, Yoshida S, Yoshida Y, Arashidani K, Takano H, Nishikawa M, Sun G, Shibamoto T*. Lung inflammation by fungus, Bjerkandera adusta isolated from Asian sand dust (ASD) aerosol and enhancement of ovalbumin-induced lung eosinophilia by ASD and the fungus in mice. Allergy Asthma Clin Immunol. 2014; 5; 10(1): 10.

24. Ren Y, Ichinose T, He M, Song Y, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T*. Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of LPS in Asian sand dust and heated dust. Allergy Asthma Clin Immunol. 2014; 9; 10(1): 30.

25. Ren Y, Ichinose T, He M, Arashidani K, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T*. Aggravation of ovalbumin-induced murine asthma by co-exposure to desert-dust and organic chemicals: an animal model study. Environ Health. 2014; 18; 13: 83.

26. Yoshida S*, Takano H, Nishikawa M, He M, Ichinose T. Effects of fetal exposure to urban particulate matter on the immune system of male mouse offspring. Biol Pharm Bull. 2012; 35(8): 1238-1243.

27. Xu YY, Wang Y, Li X, He M, Xue P, Fu JQ, Wang HH, Sun GF*. Variations in arsenic methylation capacity and oxidative DNA lesions over a 2-year period in a high arsenic-exposed population. Int Arch Occup Environ Health. 2009; 82(2): 251-258.

 

    七、研究生培养情况

2017年开始招生,在读硕士2人。

 

    八、学会及其他学术团体任职情况

中国毒理学会免疫毒理学专业委员会 委员

辽宁省环境与健康分会 常务副秘书长

沈阳市环境科学学会 常务理事

辽宁省环境损害司法鉴定机构登记评审专家

 

    九、获得奖励及荣誉称号情况

 2016年中国环境科学学会环境医学与健康分会 优秀青年学术论文

        mhe@cmu.edu.cn



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