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王惠惠 副教授
2017-04-10 09:56   审核人:

一、个人简介

王惠惠,副教授,硕士生导师,环境毒理学研究室。

 

二、教育经历

2002-2007年:中国医科大学 预防医学专业 本科

2007-2012年:中国医科大学 劳动卫生与环境卫生学 博士

 

三、工作经历(包括博士后及出国进修经历)

2011-2012年:美国亚利桑那大学 访问学者

2012-2014年:美国德克萨斯大学卫生健康中心休斯顿分校 博士后

2014-2016年:中国医科大学 公共卫生学院 环境毒理学研究室 讲师

2016-至今:中国医科大学 公共卫生学院 环境毒理学研究室 副教授

 

四、研究方向

1. Nrf2活性调节剂的筛选和应用;

2. Nrf2-ARE抑制剂在肿瘤化疗耐药中的作用;

3. Nrf1/2对巨噬细胞功能的影响。

 

五、主持课题情况

1.  国家自然科学基金青年科学基金项目:Nrf2在砷剂治疗白血病及化疗耐药性中的作用及其机制研究,2016-2018年,18万元。

 

六、文章发表情况

第一作者论文:

1.Huihui Wang, Jiayu Zhu, Zhiyuan Liu, Hang Lv, Peng Lv, Feng Chen, Jingqi Fu, Yongyong Hou, Rui Zhao, Yuanyuan Xu, Qiang Zhang, Jingbo Pi*. Silencing of long isoforms of nuclear factor erythroid 2 like 1 primes macrophages towards M1 polarization, Free Radical Biology and Medicine 117 (2018) 37–44

2.Huihui Wang#, Jiayu Zhu#, Lu Li, Yongfang Li, Hang Lv, Yuanyuan Xu, Guifan Sun, Jingbo Pi. Effects of Nrf2 deficiency on arsenic metabolism in mice. Toxicol Appl Pharmacol. 2017 Dec 15;337:111-119

3.Chen Feng#, Huihui Wang#, Jiayu Zhu, Rui Zhao, Peng Xue, Qiang Zhang, M. Bud Nelson, Weidong Qu, Bo Feng*, Jingbo Pi*. Camptothecin suppresses NRF2-ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs, British Journal of Cancer, 2017 Nov 7;117(10):1495-1506.

4.Jiayu Zhu#, Huihui Wang#, Feng Chen, Jingqi Fu, Yuanyuan Xu*, Yongyong Hou, Henry H. Kou, Cheng Zhai, M. Bud Nelson, Qiang Zhang, Melvin E. Andersen, Jingbo Pi*. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy. Free Radic Biol Med. 2016 Sep 12;99:544-556.

5.Hui Peng#, Huihui Wang#, Peng Xue, Yongyong Hou, Jian Dong, Tong Zhou, Weidong Qu, Shuangqing Peng, Jin Li,Paul L. Carmichael,Bud Nelson, Rebecca Clewell, Qiang Zhang, Melvin E. Andersen, Jingbo Pi*, Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells, Toxicol Appl Pharmacol, 2016 Feb 1; 292: 1-7

6.Weimin Chen#, Huihui Wang#, Shasha Tao, Yi Zheng, Wei Wu, Fangru Lian, Melba Jaramillo, Deyu Fang*, and Donna D Zhang*, Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival, Cell Cycle, 2013 Jul 15; 12(14): 2321-8

7.Huihui Wang, Shuhua Xi, Zhuogang Liu, Ying Yang, Quanmei Zheng, Fei Wang, Yuanyuan Xu, Yi Wang, Yi Zheng, Guifan Sun*, Arsenic methylation metabolism and liver injury of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment, Environ Toxicol, 2013 May; 28(5): 267-75

8.Huihui Wang, Shuhua Xi, Yuanyuan Xu, Fei Wang, Yi Zheng, Bing Li, Xin Li, Quanmei Zheng, Guifan Sun*, Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction, Toxicol In Vitro, 2013 Apr; 27(3): 1043-8

既非第一作者又非通讯作者论文:

9.Fu J, Zheng H, Cui Q, Chen C, Bao S, Sun J, Li L, Yang B, Wang H, Hou Y, Xu Y, Xu Y, Zhang Q, Pi J. Nfe2l1-silenced insulinoma cells acquire aggressiveness and chemoresistance. Endocr Relat Cancer. 2018 Mar;25(3):185-200

10.Kong W, Fu J, Liu N, Jiao C, Guo G, Luan J, Wang H, Yao L, Wang L, Yamamoto M, Pi J, Zhou H. Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. Nephrol Dial Transplant. 2017 Nov 6. doi: 10.1093/ndt/gfx299

11.Wu X, Yang B, Hu Y, Sun R, Wang H, Fu J, Hou Y, Pi J, Xu Y. NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes. Oxid Med Cell Longev. 2017; 2017:7417694. doi: 10.1155/2017/7417694.

12.Wu R, Wu X, Wang H, Fang X, Li Y, Gao L, Sun G, Pi J, Xu Y. Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice. Sci Rep. 2017 Mar 17;7:44424. doi: 10.1038/srep44424.

13.Fu J, Hou Y, Xue P, Wang H, Xu Y, Qu W, Zhang Q, Pi J*. Nrf2 in Type 2 diabetes and diabetic complications: Yin and Yang. Current Opinion in Toxicology. 2016;1: 9–19.

14.Fu J, Cui Q, Yang B, Hou Y, Wang H, Xu Y, Wang D, Zhang Q, Pi J. The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response. Food Chem Toxicol. 2017 Feb; 100:161-167.

15.Chen Y, Xu Y, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J.The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study. Biochem Biophys Res Commun. 2016 Sep 9;478(1):87-92.

16.Jingqi Fu, Hongzhi Zheng, Huihui Wang, Bei Yang, Rui Zhao, Chunwei Lu, Zhiyuan Liu, Yongyong Hou, Yuanyuan Xu, Qiang Zhang, Weidong Qu, and Jingbo Pi*, Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage, Oxid Med Cell Longev, 2015; 2015: 639191

17.Yongyong Hou, Yi Wang, Huihui Wang, Yuanyuan Xu*, Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: differential roles of mitogen-activated protein kinases, Toxicology, 2014 Nov 5; 325: 96-106

18.Qiang Zhang, Da Wang, Quanmei Zheng, Yi Zheng, Huihui Wang, Yuanyuan Xu, Xin Li, Guifan Sun*, Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China, Environ Res, 2014 Jul; 132: 281-9

19.Shoufang Jiang, Jing Su, Sanqiao Yao, Yanshu Zhang, Fuyuan Cao, Fei Wang, Huihui Wang, Jun Li, Shuhua Xi *, Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats, PLoS One, 2014 Apr 23; 9(4): e96041

20.Fei WangShengnan LiuShuhua Xi*Ling YanHuihui WangYingli Song, Guifan Sun, Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells, Toxicol Lett, 2013 Oct 9; 222(3): 303-11

21.Bing Li, Xin Li, Bo Zhu, Xinyu Zhang, Yi Wang, Yuanyuan Xu, Huihui Wang, Yongyong Hou, Quanmei Zheng, Guifan Sun *, Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes, Environ Toxicol, 2013 Jul; 28(7): 401-10

22.Alexandria Lau#, Yi Zheng#, Shasha Tao, Huihui Wang, Samantha A. Whitman, Eileen White, Donna D. Zhang*, Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner, Mol Cell Biol, 2013 Jun; 33(12): 2436-46

23.WeiWu#, Quan Qiu#, Huihui Wang, Samantha A. Whitman, Deyu Fang, Fangru Lian, and Donna D. Zhang*, Nrf2 is crucial to graft survival in a rodent model of heart transplantation, Oxid Med Cell Longev, 2013; 2013: 919313

24.Weimin Chen, Tao Jiang, Huihui Wang, Shasha Tao, Alexandria Lau, Deyu Fang, and Donna D. Zhang*, Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxid Redox Signal, 2012 Dec 15; 17(12): 1670-5

25.Yuanyuan Xu, Huihui Wang, Yi Wang, Yi Zheng, Guifan Sun *, Effects of folate on arsenic toxicity in Chang human hepatocytes: involvement of folate antioxidant properties, Toxicol Lett, 2010 May 19; 195(1): 44-50

26.Yuanyuan Xu, Xin Li, Quanmei Zheng, Huihui Wang, Yi Wang, Guifan Sun *, Lack of association of glutathione-S-transferase omega 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population, Mutat Res, 2009 Sep-Oct; 679(1-2): 44-9

27.Yi Wang, Yuanyuan Xu, Huihui Wang, Peng Xue, Xin Li, Bing Li, Quanmei Zheng, Guifan Sun *, Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes, Arch Toxicol, 2009 Oct; 83(10): 899-908

 

七、教材编写和期刊编委情况

Archives of Toxicology、Toxicology and Applied Pharmacology、Toxicology Reports和Clinical Toxicology期刊同行评议专家

 

八、学会及其他学术团体任职情况

   2015年—至今:辽宁省预防医学卫生毒理专业委员会 委员


    九、所获荣誉

2017年,荣获第三届毒性测试替代方法与转化毒理学(国际)学术研讨会青年优秀论文奖。



    :hhwang@cmu.edu.cn

 


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