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王惠惠 副教授
2017-04-10 09:56   审核人:

一、个人简介

王惠惠,副教授,硕士生导师,环境毒理学研究室。

 

二、教育经历

2002-2007年:中国医科大学 预防医学专业 本科

2007-2012年:中国医科大学 劳动卫生与环境卫生学 博士

 

三、工作经历(包括博士后及出国进修经历)

2011-2012年:美国亚利桑那大学 访问学者

2012-2014年:美国德克萨斯大学卫生健康中心休斯顿分校 博士后

2014-2016年:中国医科大学 公共卫生学院 环境毒理学研究室 讲师

2016-至今:中国医科大学 公共卫生学院 环境毒理学研究室 副教授

 

四、研究方向

1. Nrf2活性调节剂的筛选和应用;

2. Nrf2-ARE抑制剂在肿瘤化疗耐药中的作用;

3. Nrf1/2对巨噬细胞功能的影响。

 

五、主持课题情况

1.  国家自然科学基金青年科学基金项目:Nrf2在砷剂治疗白血病及化疗耐药性中的作用及其机制研究,2016-2018年,18万元。

 

六、文章发表情况

第一作者论文:

1.  Jiayu Zhu#, Huihui Wang#, Feng Chen, Jingqi Fu, Yuanyuan Xu*, Yongyong Hou, Henry H. Kou, Cheng Zhai, M. Bud Nelson, Qiang Zhang, Melvin E. Andersen, Jingbo Pi*. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy. Free Radic Biol Med. 2016 Sep 12;99:544-556.

2.  Hui Peng#, Huihui Wang#, Peng Xue, Yongyong Hou, Jian Dong, Tong Zhou, Weidong Qu, Shuangqing Peng, Jin Li, Paul L. Carmichael, Bud Nelson, Rebecca Clewell, Qiang Zhang, Melvin E. Andersen, Jingbo Pi*, Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells, Toxicol Appl Pharmacol, 2016 Feb 1; 292: 1-7

3.  Weimin Chen#, Huihui Wang#, Shasha Tao, Yi Zheng, Wei Wu, Fangru Lian, Melba Jaramillo, Deyu Fang*, and Donna D Zhang*, Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival, Cell Cycle, 2013 Jul 15; 12(14): 2321-8

4.  Huihui Wang, Shuhua Xi, Zhuogang Liu, Ying Yang, Quanmei Zheng, Fei Wang, Yuanyuan Xu, Yi Wang, Yi Zheng, Guifan Sun*, Arsenic methylation metabolism and liver injury of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment, Environ Toxicol, 2013 May; 28(5): 267-75

5.  Huihui Wang, Shuhua Xi, Yuanyuan Xu, Fei Wang, Yi Zheng, Bing Li, Xin Li, Quanmei Zheng, Guifan Sun*, Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction, Toxicol In Vitro, 2013 Apr; 27(3): 1043-8

既非第一作者又非通讯作者论文:

6.  Fu J, Cui Q, Yang B, Hou Y, Wang H, Xu Y, Wang D, Zhang Q, Pi J. The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response. Food Chem Toxicol. 2017 Feb; 100:161-167.

7.  Chen Y, Xu Y, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J.The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study. Biochem Biophys Res Commun. 2016 Sep 9;478(1):87-92.

8.  Jingqi Fu, Hongzhi Zheng, Huihui Wang, Bei Yang, Rui Zhao, Chunwei Lu, Zhiyuan Liu, Yongyong Hou, Yuanyuan Xu, Qiang Zhang, Weidong Qu, and Jingbo Pi*, Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage, Oxid Med Cell Longev, 2015; 2015: 639191

9.  Yongyong Hou, Yi Wang, Huihui Wang, Yuanyuan Xu*, Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: differential roles of mitogen-activated protein kinases, Toxicology, 2014 Nov 5; 325: 96-106

10. Qiang Zhang, Da Wang, Quanmei Zheng, Yi Zheng, Huihui Wang, Yuanyuan Xu, Xin Li, Guifan Sun*, Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China, Environ Res, 2014 Jul; 132: 281-9

11. Shoufang Jiang, Jing Su, Sanqiao Yao, Yanshu Zhang, Fuyuan Cao, Fei Wang, Huihui Wang, Jun Li, Shuhua Xi *, Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats, PLoS One, 2014 Apr 23; 9(4): e96041

12. Fei Wang,Shengnan Liu,Shuhua Xi*,Ling Yan,Huihui Wang,Yingli Song, Guifan Sun, Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells, Toxicol Lett, 2013 Oct 9; 222(3): 303-11

13. Bing Li, Xin Li, Bo Zhu, Xinyu Zhang, Yi Wang, Yuanyuan Xu, Huihui Wang, Yongyong Hou, Quanmei Zheng, Guifan Sun *, Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes, Environ Toxicol, 2013 Jul; 28(7): 401-10

14. Alexandria Lau#, Yi Zheng#, Shasha Tao, Huihui Wang, Samantha A. Whitman, Eileen White, Donna D. Zhang*, Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner, Mol Cell Biol, 2013 Jun; 33(12): 2436-46

15. WeiWu#, Quan Qiu#, Huihui Wang, Samantha A. Whitman, Deyu Fang, Fangru Lian, and Donna D. Zhang*, Nrf2 is crucial to graft survival in a rodent model of heart transplantation, Oxid Med Cell Longev, 2013; 2013: 919313

16. Weimin Chen, Tao Jiang, Huihui Wang, Shasha Tao, Alexandria Lau, Deyu Fang, and Donna D. Zhang*, Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxid Redox Signal, 2012 Dec 15; 17(12): 1670-5

17. Yuanyuan Xu, Huihui Wang, Yi Wang, Yi Zheng, Guifan Sun *, Effects of folate on arsenic toxicity in Chang human hepatocytes: involvement of folate antioxidant properties, Toxicol Lett, 2010 May 19; 195(1): 44-50

18. Yuanyuan Xu, Xin Li, Quanmei Zheng, Huihui Wang, Yi Wang, Guifan Sun *, Lack of association of glutathione-S-transferase omega 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population, Mutat Res, 2009 Sep-Oct; 679(1-2): 44-9

19. Yi Wang, Yuanyuan Xu, Huihui Wang, Peng Xue, Xin Li, Bing Li, Quanmei Zheng, Guifan Sun *, Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes, Arch Toxicol, 2009 Oct; 83(10): 899-908

 

七、教材编写和期刊编委情况

2014-至今:Progressive Science杂志 编委

Arch Toxicol和Toxicol Apply Pharmocol期刊 同行评议专家

 

八、学会及其他学术团体任职情况

2015年—至今:辽宁省预防医学卫生毒理专业委员会 委员


  :hhwang@cmu.edu.cn

 


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