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刘 巍 副教授
2017-04-12 14:09   审核人:

一、个人简介

刘巍,副教授、硕士生导师,环境卫生学教研室。

 

二、教育经历

2004-2009年:中国医科大学 预防医学 本科

2009-2014年:中国医科大学 劳动卫生与环境卫生学 硕博连读

 

三、工作经历(包括博士后及出国进修经历)

2014-2016年:中国医科大学 公共卫生学院 环境卫生学教研室 讲师

2016-至今:中国医科大学 公共卫生学院 环境卫生学教研室 副教授

 

四、研究方向

环境神经毒理学。

 

五、主持课题情况

1. 国家自然科学基金:内质网应激诱导线粒体钙超载及线粒体凋亡途径在甲基汞神经毒性中的作用机制。2016-2018年;18万元。

 

六、文章发表情况

1. Liu W, Xu Z*, Li H, Guo M, Yang T, Feng S, Xu B, Deng Y. Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation.Hum Exp Toxicol. 2016 Nov 11. pii: 0960327116677355.

2. Liu W, Xu Z*, Yang T, Xu B, Deng Y, Feng S. Memantine, a Low-Affinity NMDA Receptor Antagonist, Protects against Methylmercury-Induced Cytotoxicity of Rat Primary Cultured Cortical Neurons, Involvement of Ca2+ Dyshomeostasis Antagonism, and Indirect Antioxidation Effects. Mol Neurobiol. 2016 Aug 18. DOI: 10.1007/s12035-016-0020-2.

3. Liu W, Xu Z*, Yang T, Deng Y, Xu B, Feng S. Tea Polyphenols Protect Against Methylmercury-Induced Cell Injury in Rat Primary Cultured Astrocytes, Involvement of Oxidative Stress and Glutamate Uptake/Metabolism Disorders. Mol Neurobiol. 2016 Jul;53(5):2995-3009. doi: 10.1007/s12035-015-9161-y.

4. Liu W, Xu Z*, Yang T, Deng Y, Xu B, Feng S, Li Y. The protective role of tea polyphenols against methylmercury-induced neurotoxic effects in rat cerebral cortex via inhibition of oxidative stress. Free Radic Res. 2014 Aug;48(8):849-63. doi: 10.3109/10715762.2014.916039.

5. Liu W, Xu Z*, Deng Y, Xu B, Wei Y, Yang T. Protective effects of memantine against methylmercury-induced glutamate dyshomeostasis and oxidative stress in rat cerebral cortex. Neurotox Res. 2013 Oct;24(3):320-37. doi: 10.1007/s12640-013-9386-3.

6. Liu W, Xu Z*, Deng Y, Xu B, Yang H, Wei Y, Feng S. Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols. Environ Toxicol. 2014 Mar;29(3):269-83. doi: 10.1002/tox.21755.

7. Liu W, Xu Z*, Yang H, Deng Y, Xu B, Wei Y. The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury. Biol Trace Elem Res. 2011 Dec;143(3):1651-65. doi: 10.1007/s12011-011-8996-y.

8. Yang T, Xu Z*, Liu W, Feng S, Li H, Guo M, Deng Y, Xu B. Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways. Environ Toxicol. 2017 Mar;32(3):931-943.

9. Wang C, Xu B*, Song QF, Deng Y, Liu W, Xu ZF. Manganese exposure disrupts SNARE protein complex-mediated vesicle fusion in primary cultured neurons. Environ Toxicol. 2017 Feb;32(2):705-716.

10. Yang T, Xu Z*, Liu W, Xu B, Deng Y. Protective effects of Alpha-lipoic acid on MeHg-induced oxidative damage and intracellular Ca(2+) dyshomeostasis in primary cultured neurons. Free Radic Res. 2016;50(5):542-56.

11. Feng S, Xu Z*, Wang F, Yang T, Liu W, Deng Y, Xu B. Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway. Mol Neurobiol. 2017 Jan;54(1):375-391.

12. Song Q, Deng Y*, Yang X, Bai Y, Xu B, Liu W, Zheng W, Wang C, Zhang M, Xu Z. Manganese-Disrupted Interaction of Dopamine D1 and NMDAR in the Striatum to Injury Learning and Memory Ability of Mice. Mol Neurobiol. 2016 Dec;53(10):6745-6758.

13. Xu B*, Liu W, Deng Y, Yang TY, Feng S, Xu ZF. Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. PLoS One. 2015 Mar 10;10(3):e0119205.

14. Yang TY, Xu ZF*, Liu W, Xu B, Deng Y, Li YH, Feng S. Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex. Environ Toxicol Pharmacol. 2015 Jan;39(1):157-66.

15. Deng Y, Xu Z*, Xu B, Liu W, Feng S, Yang T. Antioxidative effects of schidandrin B and green tea polyphenols against mercuric chloride-induced hepatotoxicity in rats. J Environ Pathol Toxicol Oncol. 2014;33(4):349-61.

16. Deng Y*, Zhu J, Mi C, Xu B, Jiao C, Li Y, Xu D, Liu W, Xu Z. Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1-Nrf2-ARE signaling pathway in the striatum of mice. Neurotox Res. 2015 Feb;27(2):156-71.

17. Deng Y*, Jiao C, Mi C, Xu B, Li Y, Wang F, Liu W, Xu Z. Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Mol Neurobiol. 2015 Feb;51(1):68-88.

18. Feng S, Xu Z*, Liu W, Li Y, Deng Y, Xu B. Preventive effects of dextromethorphan on methylmercury-induced glutamate dyshomeostasis and oxidative damage in rat cerebral cortex. Biol Trace Elem Res. 2014 Jun;159(1-3):332-45.

19. Xu B*, Jin CH, Deng Y, Liu W, Yang TY, Feng S, Xu ZF. Alpha-synuclein oligomerization in manganese-induced nerve cell injury in brain slices: a role of NO-mediated S-nitrosylation of protein disulfide isomerase. Mol Neurobiol. 2014 Dec;50(3):1098-110.

20. Deng Y, Xu Z*, Xu B, Liu W, Wei Y, Li Y, Feng S, Yang T. Exploring cross-talk between oxidative damage and excitotoxicity and the effects of riluzole in the rat cortex after exposure to methylmercury. Neurotox Res. 2014 Jul;26(1):40-51.

21. Xu B*, Shan M, Wang F, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures. Toxicol Lett. 2013 Oct 9;222(3):239-46.

22. Xu B*, Wang F, Wu SW, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. α-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Mol Neurobiol. 2014 Feb;49(1):399-412.

23. Xu B*, Wu SW, Lu CW, Deng Y, Liu W, Wei YG, Yang TY, Xu ZF. Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures. Toxicology. 2013 Mar 8;305:71-8.

24. Xu B, Xu Z*, Deng Y, Liu W, Yang H, Wei YG. MK-801 protects against intracellular Ca(2+) overloading and improves N-methyl-D-aspartate receptor expression in cerebral cortex of methylmercury-poisoned rats. J Mol Neurosci. 2013 Jan;49(1):162-71.

25. Deng Y, Xu ZF*, Liu W, Xu B, Yang HB, Wei YG. Riluzole-triggered GSH synthesis via activation of glutamate transporters to antagonize methylmercury-induced oxidative stress in rat cerebral cortex. Oxid Med Cell Longev. 2012;2012:534705.

26. Xu B, Xu ZF*, Deng Y, Liu W, Yang HB, Wei YG. Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology. 2012 Oct 28;300(3):112-20.

27. Deng Y, Xu D, Xu B, Xu Z*, Tian Y, Feng W, Liu W, Yang H. G0/G1 phase arrest and apoptosis induced by manganese chloride on cultured rat astrocytes and protective effects of riluzole. Biol Trace Elem Res. 2011 Dec;144(1-3):832-42.

28. Yang H, Xu Z*, Liu W, Wei Y, Deng Y, Xu B. Effect of grape seed proanthocyanidin extracts on methylmercury-induced neurotoxicity in rats. Biol Trace Elem Res. 2012 Jun;147(1-3):156-64.

29. Yang H, Xu Z*, Liu W, Deng Y, Xu B. The protective role of procyanidins and lycopene against mercuric chloride renal damage in rats. Biomed Environ Sci. 2011 Oct;24(5):550-9.

30. Deng Y, Xu Z*, Liu W, Yang H, Xu B, Wei Y. Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol Trace Elem Res. 2012 May;146(2):213-23.

 

七、教材编写和期刊编委情况

2016年:《国家医师资格考试-公共卫生执业医师模拟试卷》 人民卫生出版社 编委

2016年:《国家医师资格考试-公共卫生执业助理医师模拟试卷》 人民卫生出版社 编委

2015年:《国家医师资格考试-公共卫生执业医师模拟试卷》 人民卫生出版社 编委

2015年:《国家医师资格考试-公共卫生执业助理医师模拟试卷》 人民卫生出版社 编委


:liuw@cmu.edu.cn


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