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刘盛男 副教授
2018-04-27 10:47   审核人:


一、个人简介

刘盛男,副教授,硕士生导师,环境毒理学研究室


二、教育经历

2005-2010年:中国医科大学 预防医学 本科

2010-2015年:中国医科大学 劳动卫生与环境卫生学 硕博连读


三、工作经历(包括博士后及出国进修经历)        

2015-2016年:中国医科大学 公共卫生学院 地球化学性疾病研究室

  讲师、兼职预防医学本科生辅导员

2016-2017年:美国埃默里大学 公共卫生学院 环境卫生系 访问学者

2017-至今: 中国医科大学 公共卫生学院 环境毒理学研究室 副教授


四、研究方向

应用细胞系、原代培养细胞、转基因动物模型、计算毒理学模型,致力于计算毒理学研究及环境持久性有机污染物致中枢神经系统损伤机制的研究。


五、主持课题情况

1.国家自然科学青年基金(81602824):小胶质细胞活化及其分泌的炎性因子在全氟辛烷磺酸所致中枢神经系统损伤中作用机制的研究。2017-2019年;17万元。

2.中华环境保护基金会格平绿色行动辽宁环境科研教育“123工程”(CEPF2012-123—1-1):ATF2激活转录因子与介导的炎性因子在环境砷暴露所致膀胱癌中的作用机制研究。2014-2015年;3万元。


六、文章发表情况

1. Liu J, Jin P, Liu S, Wang F, Wang X, Yang L, Xi S*. sEcad and EGF Levels Increased in Urine of Non-ferrous Metal Workers and Medium of Uroepithelial Cell Line Treated by Arsenic. Biol Trace Elem Res. 2018, 183 (1): 32-39

2. Liu J, Jin P, Lin X, Zhou Q, Wang F, Liu S, Xi S*. Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-κB pathways via ERK/MAPK in a human uroepithelial cell line. Metallomics. 2018,10 (3): 486-495

3. Liu S, Wang F, Liu J, Jin P, Wang X, Yang L, Xi S*. ATF2 partly mediated the expressions of proliferative factors and inhibited pro-inflammatory factors` secretion in arsenite human uroepithelial cells. Toxicology Research. 2017, 6: 468-476

4. Li M, Wang C, Liu J, Jin P, Wang F, Liu S, Xi S*. Low concentration arsenite activated JAK2/STAT3 signal and increased proliferative factor expressions in SV-HUC-1cells after short and long time treatment. Environ Toxicol. 2017, 32 (9): 2154-2162

5. Liu S, Zhang L, Sun Q, Wang F, Xi S*, Sun G. The Distribution in Tissues and Urine of Arsenic Metabolites After Subchronic Exposure to Dimethylarsinic Acid (DMAV) in Rats, Biological Trace Element Research. 2015, 164 (2): 219-225

6. Zhang L, Liu S, Wang F, Song Y, Sun Q, Sheng W, Xi S*, Sun G. Dimethylarsinic acid (DMA(V) ) changed the expressions of proliferative related factors and secretion of inflammatory cytokines in rat bladder, J Appl Toxicol. 2015 Feb, 35 (2): 133-141

7. Cao S, Liu S, Wang F, Liu J, Li M, Wang C, Xi S*. DMA(V) in Drinking Water Activated NF-κB Signal Pathway and Increased TGF-β and IL-1β Expressions in Bladder Epithelial Cells of Rats. Mediators Inflamm. 2015, 2015: 790652

8. Sun Q, Song Y, Liu S, Wang F, Zhang L, Xi S*, Sun G. Arsenic exposure levels in relation to different working departments in a copper mining and smelting plant. Atmospheric Environment. 2015, 118: 1-6

9. Wang F, Wang C, Liu S, Wang HH, Xi S*, Sun G. Inflammatory cytokine COX-2 mediated cell proliferation through increasing cyclin D1 expression induced by inorganic arsenic in SV-HUC-1 human uroepithelial cells. Toxicol Res. 2015, 4: 1400-1408

10. Yan N, Liu Y, Liu S, Cao S, Wang F, Wang Z, Xi S*. Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain. Mol Neurobiol. 2016,53 (7):4449-4460

11. Liu S, Sun Q, Wang F, Zhang L, Song Y, Xi S*, Sun G. Arsenic induced overexpression of inflammatory cytokines based on the human urothelial cell model in vitro and urinary secretion of individuals chronically exposed to Arsenic. Chemical Research in Toxicology. 2014, 27(11): 1934–1942

12. Wang F, Liu S, Sun G, Zhang L, Song Y, Sheng W, Xi S*, Sun G. Urinary VEGF and PGE2 levels and the association with arsenical metabolites in copper-smelting workers. Occup Environ Med. 2014, 71(10): 675-680

13. Xi S, Sun Q, Wang F, Liu S, Yan L, Zhang L, Song Y, Yan N, Sun G*. The factors influencing urinary arsenic excretion and metabolism of workers in steel and iron smelting foundry. J Expo Sci Environ Epidemiol. 2014, 24 (1): 36-41

14. Zhang Z, Zhou B, Wang H, Wang F, Song Y, Liu S, Xi S*. Maize purple plant pigment protects against fluoride-induced oxidative damage of liver and kidney in rats. Int J Environ Res Public Health. 2014, 11(1): 1020-1033

15. Wang F, Liu S, Xi S*, Yan Y, Wang H, Song Y, Sun G. Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells. Toxicol Lett. 2013, 222(3): 303-311

16. Liu S, Wang F, Yan L, Zhang L, Song Y, Xi S*, Jia J, Sun G. Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic. Arch Toxicol. 2013, 87(6): 981-989

17. Yan L, Liu S, Wang C, Wang F, Song Y, Yan N, Xi S*, Ziyou Liu, Guifan Sun. JNK and NADPH oxidase involved in fluorideinduced oxidative stress in BV-2 microglia cells. Mediators Inflamm. 2013, 2013: 895975



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