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远山千春 教授
2017-04-13 10:17   审核人:

一、个人简介

逺山千春,教授,东京大学医学系研究科疾患生命工学センター健康环境医工学部門。

 

二、教育经历

1972年获得日本东京大学卫生学学士学位;

1981年获美国罗切思特大学毒理学博士学位。

 

三、工作经历

曾职于日本国立环境研究所,先后担任助理研究员、研究员、实验室主任及环境卫生学部部长等职务。2005-至今,他受聘为日本东京大学医学系环境卫生学教授。

 

四、研究方向

主要研究领域为环境毒理学,涉及毒理学的基础性研究和多种环境化学污染物风险性评估,主要研究方向包括:1. 分子靶向毒理学;2. 行为/认知毒理学;3. 表观遗传毒理学。

 

五、所获荣誉

The Japanese Society of Hygiene, Young Scientist Encouragement Award, 1988

The Japanese Society of Risk Analysis, Distinguished Achievement Award, 2008

The Japanese Society of Hygiene, Distinguished Achievement Award, 2010

 

七、文章发表情况(代表性论文

1.Sugai E, Yoshioka W, Kakeyama M, Ohsako S, Tohyama C (2014) In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet. J Appl Toxicol 34(3):296-306: PMID23749557.

2.Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C (2013) Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins. Arch Toxicol: PMID24292196 Kurita H, Ohsako S, Hashimoto S, Yoshinaga J, Tohyama C (2013) Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene. J NutrBiochem 24(1):256-66: PMID22917840.

3.Yoshioka W, Endo N, Kurashige A, Haijima A, Endo T, Shibata T, Nishiyama R,Kakeyama M, Tohyama C (2012) Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region. Sci Rep 2:783:PMID23136640.

4.Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C (2012) Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. Toxicol Sci127(2):547-54: PMID22430074

5.Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C (2012)Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation. PLoS One 7(12):e50741:PMID23251380.

6.Yoshioka W, Higashiyama W, Tohyama C (2011) Involvement of microRNAs in dioxin-induced liver damage in the mouse. Toxicol Sci 122(2):457-65:PMID21602190.

7.Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, Morris RG1. (2011) Schema-dependent gene activation and memory encoding in neocortex.Science 333(6044):891-5: PMID21737703.

8.Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M,Ohkubo S (2011) Polychlorinated dioxins, furans, and biphenyls in blood of children and adults living in a dioxin-contaminated area in Tokyo. Environ Health Prev Med16(1):6-15: PMID21432212.

9.Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M (2011)Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behav Brain Res 221(1):172-81: PMID21377499.

10.Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C (2010) In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. Neurotoxicology 31(4):385-90:PMID20398696.

11.Ohsako S, Fukuzawa N, Ishimura R, Kawakami T, Wu Q, Nagano R, Zaha H, Sone H, Yonemoto J, Tohyama C (2010) Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse. Biol Reprod 82(3):636-43:PMID20007409.

12.Dong B, Nishimura N, Vogel CF, Tohyama C, Matsumura F (2010) TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys. Biochem Pharmacol 79(3):487-97:PMID19782052.

13.Alam MS, Ohsako S, Matsuwaki T, Zhu XB, Tsunekawa N, Kanai Y, Sone H,Tohyama C, Kurohmaru M (2010) Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate. Reproduction 139(2):427-37: PMID19903717.

14.Yoshioka W, Akagi T, Nishimura N, Shimizu H, Watanabe C, Tohyama C (2009)Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney. J Toxicol Sci 34(5):519-25: PMID19797860.

15.Nohara K, Suzuki T, Ao K, Murai H, Miyamoto Y, Inouye K, Pan X, Motohashi H, Fujii-Kuriyama Y, Yamamoto M, Tohyama C (2009) Constitutively active arylhydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production orantibody production. Int Immunol 21(7):769-77: PMID19461128.

16.Kurita H, Yoshioka W, Nishimura N, Kubota N, Kadowaki T, Tohyama C (2009) Arylhydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice. J Appl Toxicol 29(8):689-94:PMID19623578.

17.Kawakami T, Ito T, Ohsako S, Shiizaki K, Murakami Y, Hirowatari K, Sato M,Tohyama C (2009) Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats. J Toxicol Sci 34(2):209-20: PMID19336978.


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