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佟海燕 研究员
2017-04-13 10:48   审核人:

一、个人简介

佟海燕 ,博士,研究员,美国环境保护署健康与环境效应实验室环境卫生系临床研究部,首席研究员。

 

二、教育经历

1988年,中国医科大学,硕士学位;

1998年,美国佛罗里达大学医学院生理学系,博士学位。

 

三、工作经历

1988-1993年,首都医科大学附属友谊医院妇产科,住院医师;

1994-1998年,美国佛罗里达大学医学院生理学系,助理研究员;

1998-2001年,美国国立卫生院环境健康科学研究所,信号转导实验室,博士后研究工作;

2001-2002年,美国北卡罗来纳大学医学院麻醉科,助理研究教授;

2002-2003年,美国国立卫生院环境健康科学研究所,信号转导实验室,研究学者;

2003-2006年,美国杜克大学医学中心病理学系,助理研究教授;2006-2010年,美国环境保护署健康与环境效应实验室环境卫生学系临床研究部,R-Authority 研究员;

2010-至今,美国环境保护署健康与环境效应研究实验室环境卫生系临床研究部,生物学家/首席研究员。

 

四、研究方向

大气污染暴露对人类和实验动物心肺功能产生的影响,及利用动物模型研究环境大气颗粒污染物(PM2.5PM10)暴露致心血管毒性作用的毒理学机制。近期其主要科研项目为利用心脏缺血/再灌注模型来检测多环境污染源暴露对心血管的影响;同时,还致力于膳食干预是否可作为保护性因素来减轻大气污染对人体心血管造成的负面效应。

 

五、所获荣誉

1998-2001年,荣获美国国立卫生研究院内部研究培训奖

2001年,荣获美国国立卫生研究院优秀奖

2002年,荣获美国国立卫生研究院优秀研究员奖

2003年,荣获国际心脏研究学会(北美地区)“青年研究奖;荣获美国心脏协会“新研究员奖”;

2010-2013年,连续三年荣获美国环保局科技成果奖

2014年,荣获美国环保局开拓创新工程奖

 

七、文章发表情况(代表性论文

1.  Tong, H., F. Lakhdir, and CE. Wood. Endogenous prostanoids modulate the ACTH and AVP responses to hypotension in late-gestation fetal sheep.  American Journal of Physiology. 1998; 275:R735-741.

2.  Tong, H., E. Richards, and CE. Wood. Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion. Journal of the Society for Gynecologic Investigation. 1999; 6(3):127-135.

3.  Wood, CE and H. Tong. Central nervous system regulation of reflex responses to hypotension during fetal life. American Journal of Physiology. 1999; 277:R1541-1552.

4.  Tong, H. and CE. Wood. Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep. American Journal of Physiology. 1999; 277:R1268-1273.

5.  Tong, H., H. Dhillon, and CE. Wood. Induction of PGHS-2 mRNA in response to cerebral hypoperfusion in late-gestation fetal sheep. Prostaglandins and other Lipid Mediators. 2000; 62:165-172.

6.  Tong, H., W. Chen, RE. London, E. Murphy, and C. Steenbergen. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol-3-kinase.Journal of Biological Chemistry. 2000; 275(16):11981-11986.

7.  *Tong, H., W. Chen, C. Steenbergen, and E. Murphy. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circulation Research. 2000; 87(4):309-315.

8.  Lakhdir, F., H. Tong,and C.E. Wood. Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma renin activity. Reproduction, Fertility and Development. 2001; 13:119-124.

9.  Tong, H., K.E. Gridley, and CE. Wood. Induction of immunoreactive PGHS-1, PGHS-2 and Fos in response to cerebral hypoperfusion in late-gestation fetal sheep. The Journal of the Society for Gynecologic Investigation. 2002;9(6):342-350.

10. Tong, H., K. Imahashi, C. Steenbergen, and E. Murphy. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective. Circulation Research. 2002; 90:377-379.

11. Murphy E., H. Tong, and C. Steenbergen.  Preconditioning: Is the Akt-ion in the PI3K pathway? Journal of Molecular and Cellular Cardiology.  2003;35(9):1021-1025.

12. Tong, H., HA. Rockman, WJ. Koch, C. Steenbergen, and E. Murphy. G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circulation Research. 2004; 94:1133-1141.

13. Tong, H., D. Bernstein, E. Murphy, and C. Steenbergen. The role of - adrenergic receptor signaling in cardioprotection. FASEB Journal. 2005; 19(8): 983-985.

14. Cho, SH., H.Tong,JK. McGee, RW. Baldauf, QT. Krantz, and MI. Gilmour. Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway. Environmental Health Perspectives. 2009; 117(11):1682-1689.

15. *Tong, H., JK. McGee, RK. Saxena, UP. Kodavanti, RB. Devlin and MI. Gilmour. Influence of acid functionalization on the cardio-pulmonary toxicity of carbon nanotubes and carbon black particle in mice. Toxicology and Applied Pharmacology. 2009; 239(3):224-232.

16. *Tong, H., WY .Cheng, JM. Samet, MI. Gilmour, and RB. Devlin. Differential cardiopulmonary effects of size-fractionated ambient particulate matter in mice. Cardiovascular Toxicol. 2010; 10(4):259-267.

17. Cheng, WY.H. Tong, EW. Miller, CJ. Chang, J. Remington, R M. Zucker, PA. Bromberg, JM. Sametand TJ. Hofer.  An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells. Environmental Health Perspectives. 2010; 118(7):902-908.

18. Zhou, RH. AE. Vendrov, I. Tchivilev, XL. Niu, KC. Molnar, M. Rojas, JD. Carter, H. Tong, GA. Stouffer,NR. Madamanchiand MS. Runge. Mitochondrial Oxidative Stress in Aortic Stiffening with Age. Arterioscler Thromb Vasc Biol. 2012; 32:745-755.

19. *Tong, H., AG. Rappold, D. Diaz-Sanchez, SE. Steck, J. Berntsen, WE. Cascio,RB. Devlin, JM. Samet. Omega-3 fatty acid supplementation attenuates particulate air pollution induced cardiac effects and lipid changes in healthy middle-aged adult volunteers. Environmental Health Perspectives.2012; 120(7):952-957.

20. Ghio, AJ.H. Tong, JM. Soukup, LA. Dailey, WY. Cheng, JM. Samet, MJ. Kesic, PA. Bromberg, JL. Turi, D. Upadhyay, GR.Budinger, and GM. Mutlu.Sequestration of mitochondrial iron by silica particles initiates a biological effect. AmericanJournal of Physiology Lung Cell Mol Physiol. 2013; 305(10):L712-724.

21. McIntosh-Kastrinsky, R., D. Diaz-Sanchez, K. Sexton, CM. Jania, J. Zavala, SL. Tilley, I. Jaspers, MI. Gilmour, RB. Devlin, WE. Cascio and *H. Tong.Photochemically altered air pollution mixtures and contractile parameters in isolated murine hearts before and after ischemia. Environmental Health Perspectives. 2013; 121(11-12):1344-1348.

22. Ghio, A., H. Tong, J. Soukup, L. Dailey, E. Boykin, MI. Gilmour, Ingram, Roggli, Goldstein, Reynolds. Biological effects of desert dust in respiratory epithelial cells and a murine model. Inhalation Toxicology. 2014; 26(5):299-309.

23. *Tong, H., AG. Rappold, M. Caughey, AL. Hinderliter, DW. Graff, J. Berntsen, WE. Cascio,RB. Devlin, and JM. Samet. Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers. Inhalation Toxicology. 2014;26(6):319-326.

24. Kim, YH., H. Tong, M. Daniels, E. Boykin, QT Krantz, J. McGee, M. Hays, K. Kovalcik, J. Dye and MI. Gilmour. Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices. Particle and Fibre Toxicology. 2014; 11:29.

25. Kurhanewicz, N.,R. McIntosh-Kastrinsky, H.Tong, L. Walsh, AK. Farraj, and MS. Hazari. Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responses. Particle and Fibre Toxicology. 2014; 11:54.

26. Wages, P, Silbajoris, R, Speen, AM, Brighton, LE, Henriquez, A,Tong, H, Bromberg, PA, Simmons, S, and Samet, JM.Role of H2O2 in the Oxidative Effects of Zinc Exposure in Human Airway Epithelial Cells. Redox Biology. 2014143.

27. *Tong, H., AG. Rappold, M. Caughey, AL. Hinderliter, M. Bassett, T. Montilla, M. Case, J. Berntsen, PA. Bromberg, WE. Cascio, D. Diaz-Sanchez, RB. Devlin, and JM. Samet. Olive oil supplementation attenuates endothelial dysfunction caused by concentrated ambient particulate matter exposure in healthy human volunteers. Environmental Health Perspectives. (In press)

28. Murphy E, H. Tong, and C. Steenbergen.  A role for the phosphatidylinositol-3-kinase pathway in preconditioning.  Myocardial ischemia and preconditioning in Progress in experimental cardiology. 2003 (6):275-282. Editors: Dhalla, N.S. N. Takeda, M. Singh, A. Lukas. Kluwer Academic Publishers, Boston, MA. 2003.

29. Steenbergen, C., H. Tong, andE. Murphy. PI3 Kinase and Cardioprotection. Cardiovasc J S Afr.2004; 15(4 Suppl 1):S4.

 

 


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