1

Advances   in computational methods along the exposure to toxicological response   paradigm

Computational   approaches

2

Predicting   nonlinear relationship between external and internal concentrations with   physiologically based pharmacokinetic modeling

3

PBK   modelling of topical application and characterisation of the uncertainty of C_max   estimate: A case study approach

4

The   path via pathway-based approaches towards safety assessment: A concise review

5

Prediction   of drug-induced liver injury and cardiotoxicity using chemical structure and in   vitro assay data

6

Identification   of nonmonotonic concentration-responses in Tox21 high-throughput screening   estrogen receptor assays

7

Application   of ARE-reporter systems in drug discovery and safety assessment

Cell-based in   vitro assays

8

NRF2/PGC-1α-mediated   mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human   neuroblastoma SH-SY5Y cells

9

NRF2-ARE   signaling is responsive to haloacetonitrile-induced oxidative stress in human   keratinocytes

10

Chronic   arsenic exposure suppresses ATM pathway activation in human keratinocytes

11

Genotoxicity,   oxidative stress and transcriptomic effects of nitenpyram on human bone   marrow mesenchymal stem cells

12

Assessment   of intestinal injury of hexavalent chromium using a modified in vitro   gastrointestinal digestion model

Micro-physiological devices and low species   animal models

13

The   disruption on gut microbiome of Decabromodiphenyl ethane exposure in the   simulator of the human intestinal microbial ecosystem (SHIME)

14

Integrative   description of changes occurring on zebrafish embryos exposed to   water-soluble crude oil components and its mixture with a chemical surfactant

15

Combining   phenotypic profiling and targeted RNA-Seq reveals linkages between   transcriptional perturbations and chemical effects on cellmorphology:   Retinoic acid as an example

Omics technologies

16

Assessing   the neurotoxicity of airborne nano-scale particulate matter in human   iPSC-derived neurons using a transcriptomics benchmark dose model

17

Time-resolved   quantitative phosphoproteomics reveals cellular responses induced by caffeine   and coumarin

18

Quantitative   phosphoproteomics reveal cellular responses from caffeine, coumarin and   quercetin in treated HepG2 cells

19

Titanium   dioxide nanoparticles induced reactive oxygen species (ROS) related changes   of metabolomics signatures in human normal bronchial epithelial (BEAS-2B)   cells

20

Developmental   arsenic exposure induces dysbiosis of gut microbiota and disruption of plasma   metabolites in mice

21

Targeted   Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening:   Analytical and testing considerations to inform a PFAS stock quality evaluation   framework

Chemical   standardization