刘万洋教授-中国医科大学公共卫生学院

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刘万洋教授

时间：2017-04-07浏览次数：次

一、个人简介

刘万洋，教授，博士生导师，营养与食品卫生学教研室。

二、教育经历

1993-1998年：中国医科大学预防医学本科

2002-2005年：中国医科大学劳动卫生与环境卫生学硕士

2006-2010年：京都大学环境卫生学博士（日本文部省奖学金资助）

三、工作经历（包括博士后及出国进修经历）

1998-2007年：辽宁省疾病预防控制中心地方病防治所医师/主治医师

2010-2013年：京都大学医学研究科环境卫生学教研室博士后（日本学术振兴会外国人特别研究员奖学金资助）

2013-2014年：中国医科大学公共卫生学院营养与食品卫生学教研室讲师

2014-2019年：中国医科大学公共卫生学院营养与食品卫生学教研室副教授

2017-2018年：京都大学环境卫生学访问学者（国家留学基金-辽宁省地方合作项目资助）

2019-至今：中国医科大学公共卫生学院营养与食品卫生学教研室教授

四、研究方向

遗传、营养与慢性病；多组学健康医疗大数据

五、主持课题情况

1. 国家自然科学基金：高同型半胱氨酸环境下RNF213基因功能缺失通过血管内皮细胞外泌体介导烟雾病血管平滑肌细胞表型转化的机制研究。2026-2029；49万元。

2. 国家自然科学基金：烟雾病新致病基因鉴定及其生物标志物研究。2022-2025；55万元。

3. 国家自然科学基金：烟雾病和颅内动脉狭窄闭塞患者致病基因的遗传流行病学研究。2016-2019；57万元。

4. 国家自然科学基金：脑发育关键期碘缺乏损伤海马学习记忆的机制。2006-2008；23万元。

5. 辽宁省科技厅2023年助力中国医科大学高质量发展专项：烟雾病的生物标志物鉴定及其风险评估研究。2023-2025；30万元

6. 辽宁省教育厅科学研究一般项目：烟雾病和颅内动脉狭窄闭塞致病基因鉴定。2015-2018；6万元。

7. 日本学术振兴会外国人特别研究员科研奖励基金：烟雾病发病机制的研究。2010-2012年；210万日元。

8. 辽宁省省级大学生创新创业项目创新训练：RNF213功能缺失通过调节HIF-1α致内皮细胞异常表型转换的机制研究。2025-2026；0.5万元。

9. 大学生创新创业项目创新训练国家级：基于RNA高通量测序的烟雾病mRNA-miRNA-circRNA差异表达及关联分析。2020-2021；1.0万元。

10. 辽宁省省级大学生创新创业项目创新训练甲类：中国汉族烟雾病主要致病基因鉴定。2016-2017；0.5万元。

六、获得科学技术奖情况

1. 辽宁省科技进步二等奖：碘缺乏对学龄儿童智力损伤的调查及致脑发育障碍机制的研究。2011年；第四完成人。

2. 中华预防医学会科学技术奖三等奖：碘缺乏对学龄儿童智力损伤的调查及致脑发育障碍机制的研究。2011年；第四完成人。

3. 辽宁省科技进步三等奖：碘缺乏致亚临床损伤的流行病学调查及致海马神经发育损害的研究。2005年；第七完成人。

七、文章发表情况（^*通讯作者）

1. Shen J^#, Wang Y^# (^#equal contribution), Qin Y, Chen G, Xu J, Li Y, Hou Y, Liu Y, Liu W^*. RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease. Mol Neurobiol. 2025 Jun 4. (2024 IF: 4.3)

2. Xu J^#, Zou Z^#, Liu W^#, Zhang Q^# (^#equal contribution), Shen J, Hao F, Chen G, Yu D, Li Y, Zhang Z, Qin Y, Yang R, Wang Y^*, Duan L^*. HAPLN3 p.T34A contributes to incomplete penetrance of moyamoya disease in Chinese carrying RNF213 p.R4810K. Eur J Neurol. 2024 Dec;31(12):e16473. (2024 IF: 3.9)

3. Wang Y^#, Zou Z^# (^#equal contribution), Yang Z, Zhang Z, Xu J, Hao F, Shen J, Han C, Liu W^*, Duan L^*. Whole Exome Sequencing and Functional Validation Identify CAPN1 Variants as a Cause of Chinese Moyamoya Disease. Genes & Diseases. 2024, 11(4):101090. (2024 IF: 9.4)

4. Ihara M^*, Yamamoto Y, Hattori Y, Liu W, Kobayashi H, Ishiyama H, Yoshimoto T,Miyawaki S, Clausen T, Bang OY, Steinberg GK, Tournier-Lasserve E, Koizumi A. Moyamoya disease: diagnosis and interventions. Lancet Neurol. 2022 May 20:S1474-4422(22)00165-X. (2022IF: 48.0, Times Cited: 263)

5. Liu W^#, Morito D^#, Takashima S^#, Mineharu Y^#, Kobayashi H^#, Hitomi T^#, Hashikata H^#, Matsuura N^# (^#equal contribution), Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N^*, Koizumi A^*. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One. 2011;6(7):e22542. (2011IF= 4.092, Times Cited: 623, ESI高被引论文)

6. Wang Y^#, Zhang Z^#, Wei L^# (^#equal contribution), Zhang Q, Zou Z, Yang L, Li D, Shang M, Han C, Mambiya M, Bao X, Li Q, Hao F, Zhang K, Wang H, Liu S, Liu M, Zeng F, Nie F, Wang K^*, Liu W^*, Duan L^*. Predictive role of heterozygous p.R4810K of RNF213 in the phenotype of Chinese moyamoya disease. Neurology. 2020,94(7):e678-e686. (2020IF: 9.910, Times Cited: 67)

7. Wang X, Wang Y, Nie F, Li Q, Zhang K, Liu M, Yang L, Zhang Q, Liu S, Zeng F, Shang M, Liang M, Yang Y, Liu X, Liu W^*. Association of genetic variants with moyamoya disease in 13,000 individuals A meta-analysis. Stroke. 2020;51(6):1647-1655. (2020IF: 7.914, Times Cited: 34)

8. Mineharu Y^#, Liu W^# (^#equal contribution), Inoue K, Matsuura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A^*. Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology. 2008;70 (24 Pt 2):2357-2363. (IF= 7.043, Times Cited: 152)

9. Wang Y, Yang L, Wang X, Zeng F, Zhang K, Zhang Q, Liu M, Liu S, Shang M, Li Q, Yang Y, Liang M, Liu W^*. Meta‐analysis of genotype and phenotype studies to confirm the predictive role of the RNF213 p.R4810K variant for moyamoya disease. Eur J Neurol. 2021;28(3):823-836. (2020IF: 6.288)

10. Wang X^#, Liang M^# (^#equal contribution), Zeng F, Wang Y, Yang Y, Nie F, Shang M, Ta N, Wen L, Ou L, Yang Z, Liu W^*. Predictive role of modifiable factors in stroke: an umbrella review. BMJ Open. 2022 Jun 16;12(6):e056680. (2021 IF: 3.006).

11. Wang Y^#, Zhang Z^#(^#equal contribution), Wang X, Zou Z, Ta N, Hao F, Yang Y, Li D, Liang M, Han C, Bao X, Ou L, Wang H, Yang Z, Yang R, Zeng F, Shang M, Nie F, Liu W^*, Duan L^*. Validation and extension study exploring the role of RNF213 p.R4810K in 2,877 Chinese moyamoya disease patients. J Stroke Cerebrovasc Dis. 2021 Nov;30(11):106071. (2021 IF: 2.677).

12. Ta N^#, Liu M^# (^#equal contribution),Wang Y, Zeng F, Nie F, Shang M, Wang X, Yang Y, Liang M, Wen L, Ou L, Yang Z, Liu W^*, Liu X^*. Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China. Rev Cardiovasc Med. 2021 Sep 24;22(3):895-901. (2021 IF: 4.430).

13. Wang X^#, Zhang Z^# (^#equal contribution), Wang Y, Zou Z, Ta N, Hao F, Shang M, Li D, Zeng F, Han C, Nie F, Bao X, Yang Y, Wang H, Liang M, Yang R, Ou L, Wen L, Yang Z, Liu W^*, Duan L^*. Clinical and Genetic Risk Factors of Long-Term Outcomes after Encephaloduroarteriosynangiosis in Moyamoya Disease in China. J Stroke Cerebrovasc Dis. 2021 Jul;30(7):105847. (2021IF: 2.677).

14. Liu M, Shang M, Wang Y, Li Q , Liu X, Yang L, Zhang Q, Zhang K, Liu S, Nie F, Zeng F, Wen Y, Liu W^*. Effects of TNF-α-308G/A polymorphism on the risk of diabetic nephropathy and diabetic retinopathy: an updated meta-analysis. Horm Metab Res. 2020 Oct;52(10):724-731. (2020IF: 2.936)

15. Mambiya M^#, Shang M^#(^#equal contribution), Wang Y, Li Q, Liu S, Yang L, Zhang Q, Zhang K, Liu M, Nie F, Zeng F, Liu W^*. The Play of Genes and Non-Genetic Factors on Types 2 Diabetes. Front Public Health. 2019 Nov 19;7:349. (IF= 2.483)

16. Nie F, Yu M, Zhang K, Yang L, Zhang Q, Liu S, Liu M, Shang M, Zeng F, Liu W^*. Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies. Int J Clin Oncol. 2020,25(2),312-321. (IF= 3.402)

17. Liu S, Liu M^#(^#equal contribution), Li Q, Liu X, Wang Y, Mambiya M, Zhang K, Yang L, Zhang Q, Shang M, Zeng F, Nie F, Liu W^*. Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure. Biosci Rep. 2019 Dec 20;39(12). (IF= 2.942)

18. Nie F, Yu M, Liu M, Shang M, Zeng F, Liu W^*. NINJ2 gene polymorphisms and susceptibility to ischemic stroke: an updated meta-analysis. Curr Neurovasc Res. 2019 Jun 18. (IF= 1.649)

19. Liu M^#, Liu S^# (^#equal contribution) , Shang M, Liu X, Wang Y, Li Q, Mambiya M, Yang L, Zhang Q, Zhang K, Nie F, Zeng F, Liu W^*. Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non-alcoholic fatty liver disease: An updated meta-analysis. Mol Genet Genomic Med. 2019 Mar 5:e624. (IF= 1.995)

20. Wang Y^#, Mambiya M^#, Li Q, Yang L, Jia H, Han Y, Liu W^*. RNF213 p.R4810K polymorphism and the risk of Moyamoya Disease, Intracranial Major Artery Stenosis/Occlusion and Quasi-Moyamoya Disease: a meta-analysis. J Stroke Cerebrovasc Dis. 2018,27(8): 2259-2270. (IF= 1.646)

21. Wang Y, Li Q, Mambiya M, Zhang K, Yang L, Zhang Q, Liu S, Liu M, Yin J, Liu W^*. A Meta-Analysis of the Association between MicroRNA-196a2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian population. J Stroke Cerebrovasc Dis. 2018,27(11):3008-3019. (IF= 1.646)

22. Liu W, Senevirathna ST, Hitomi T, Kobayashi H, Roder C, Herzig R, Kraemer M, Voormolen MH, Cahová P, Krischek B^*, Koizumi A^*. Genomewide association study identifies no major founder variant in Caucasian moyamoya disease. J Genet. 2013;92(3):605-609. (IF= 1.013, Times Cited: 41)

23. Liu W, Yin T, Okuda H, Harada KH, Li Y, Xu B, Yang J, Wang H, Fan X, Koizumi A, Miyata T^*. Protein S K196E mutation, a genetic risk factor for venous thromboembolism, is limited to Japanese. Thromb Res. 2013; 132(2):314-315. (IF= 2.427)

24. Liu W, Takahashi S, Sakuramachi Y, Harada KH, Koizumi A^*. Polyfluorinated telomers in indoor air of Japanese houses. Chemosphere 2013;90(5):1672-1677. (IF= 3.499)

25. Liu W, Tanabe M, Harada KH, Koizumi A^*. Levels of urinary isoflavones and lignan polyphenols in Japanese women. Environ Health Prev Med. 2013;18(5):394-400.

26. Liu W, Harada KH, Hitomi T, Kobayashi H, Koizumi A^*. Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian populations. Neurol Med Chir (Tokyo). 2012;52(5):299-303. (IF= 0.493, Times Cited: 125)

27. Liu W, Chen S, Harada KH, Koizumi A^*. Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan. Chemosphere 2011;85(11):1734-1741. (IF= 3.206)

28. Liu W, Dong J, Wang Y, Xi Q, Chen J^*. Developmental iodine deficiency and hypothyroidism impaired in vivo synaptic plasticity and altered PKC activity and GAP-43 expression in rat hippocampus. Nutr Neurosci. 2010;13(5):213-222. (IF= 1.301)

29. Liu W^#, Hashikata H^#, Inoue K^#(^#equal contribution), Matsuura N, Mineharu Y, Kobayashi H, Kikuta KI, Takagi Y, Hitomi T, Krischek B, Zou LP, Fang F, Herzig R, Kim JE, Kang HS, Oh CW, Tregouet DA, Hashimoto N, Koizumi A^*. A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians. Environ Health Prev Med. 2010;15(2): 94-104. (Times Cited: 53)

30. Kobayashi H^#, Abe K^#, Matsuura T^# (^#equal contribution), Ikeda Y, Hitomi T, Akechi Y, Habu T, Liu W, Okuda H, Koizumi A^*. Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am J Hum Genet. 2011;89(1):121-130. (IF= 10.603, Times Cited: 244)

31. Kobayashi H, Kabata R, Kinoshita H^*, Morimoto T, Ono K, Takeda M, Choi J, Okuda H, Liu W, Harada KH, Kimura T, Youssefian S, Koizumi A. Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice. Pulm Circ. 2018 Jul-Sep;8(3):2045894018778155. (IF= 2.075)

32. Cao Y, Harada KH, Liu W, Yan J, Zhao C, Niisoe T, Adachi A, Fujii Y, Nouda C, Takasuga T, Koizumi A^*. Short-chain chlorinated paraffins in cooking oil and related products from China. Chemosphere. 2015;138:104-111. (IF= 3.340, Times Cited: 64)

33. Nanayakkara S, Senevirathna ST, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne ED, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A^*. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014;56(1):28-38. (IF= 1.096, Times Cited: 118)

34. Mineharu Y^*, Takagi Y, Takahashi JC, Hashikata H, Liu W, Hitomi T, Kobayashi H, Koizumi A, Miyamoto S. Rapid progression of unilateral moyamoya disease in a patient with a family history and an RNF213 risk variant. Cerebrovasc Dis. 2013;36(2):155-157. (IF= 3.698, Times Cited: 36)

35. Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A^*. Ablation of Rnf213 retards progression of diabetes in the Akita mouse. Biochem Biophys Res Commun. 2013;432(3):519-525. (IF= 2.281, Times Cited: 49)

36. Yan J, Takahashi T, Ohura T, Adachi H, Takahashi I, Ogawa E, Okuda H, Kobayashi H, Hitomi T, Liu W, Harada KH, Koizumi A^*. Combined linkage analysis and exome sequencing identifies novel genes for familial goiter. J Hum Genet. 2013;58(6):366-377. (IF= 2.526)

37. Koizumi A^*, Kobayashi H, Liu W, Fujii Y, Senevirathna STMLD, Nanayakkara S, Okuda H, Hitomi T, Harada KH, Takenaka K, Watanabe T, Shimbo S. P.R4810K, a Polymorphism of RNF213, the Susceptibility Gene for Moyamoya Disease, Is Associated with Blood Pressure. Environ Health Prev Med. 2012; 18(2): 121-129. (Times Cited: 65)

38. Dong J^#, Liu W^# (^#equal contribution), Wang Y, Hou Y, Xu H, Gong J, Xi Q, Chen J^*. Developmental iodine deficiency and hypothyroidism impair spatial memory in adolescent rat hippocampus: involvement of CaMKII, Calmodulin and Calcineurin. Neurotox Res. 2011;19(1):81-93. (IF= 3.514)

39. Mineharu Y, Liu W, Hashikata H, Inoue K, Matsuura N, Kobayashi H, Kikuta K, Takagi Y, Hitomi T, Hashimoto N, Miyamoto S, Koizumi A^*. A polymorphism in Raptor is associated with moyamoya disease in the East Asian populations. Stroke 2011;42(3): E142-E142. Meeting abstract (IF= 5.729)

40. Hashikata H^#, Liu W^# (^#equal contribution), Inoue K, Mineharu Y, Yamada S, Nanayakkara S, Matsuura N, Hitomi T, Takagi Y, Hashimoto N, Miyamoto S, Koizumi A^*. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. Stroke. 2010 ;41(6):1138-1144. (IF= 5.756, Times Cited: 45)

41. Gong J, Dong J, Wang Y, Xu H, Wei W, Zhong J, Liu W, Xi Q, Chen J^*. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate Caveolin-1, and down-regulate Synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-139. (IF= 4.650, Times Cited: 32)

42. Dong J, Liu W, Wang Y, Xi Q, Chen J^*. Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats. Int J Dev Neurosci. 2010;28(7):589-596. (IF= 1.938)

43. Gong J, Liu W, Dong J, Wang Y, Xu H, Wei W, Zhong J, Xi Q, Chen J^*. Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of Doublecortin and NCAM-180. BMC Neurosci. 2010;11:50. (IF= 3.091, Times Cited: 49)

44. Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J^*. Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats. BMC Neurosci. 2009;10:149. doi:10.1186/1471-2202-10-149. (IF= 2.744)

45. Tang Z, Liu W, Yin H, Wang P, Dong J, Wang Y, Chen J^*. Investigation of intelligence quotient and psychomotor development in schoolchildren in areas with different degrees of iodine deficiency. Asia Pac J Clin Nutr. 2007;16(4):731-737. (IF= 1.180)

46. Inoue S, Liu W, Inoue K, Mineharu Y, Takenaka K, Yamakawa H, Abe M, Jafar JJ, Herzig R, Koizumi A^*. Combination of linkage and association studies for brain arteriovenous malformation. Stroke. 2007;38 (4):1368-1370. (IF= 6.296)

47. Dong J, Yin H, Liu W, Wang P, Jiang Y, Chen J^*. Congenital iodine deficiency and hypothyroidism impair LTP and decrease C-fos and C-jun expression in rat hippocampus. Neurotoxicology. 2005;26:417-426. (IF= 2.576, Times Cited: 92)

48. Chen Y, Chen J^*, Dong J, Liu W. Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett. 2005;155:353-360. (IF= 2.430)

八、研究生培养情况

硕士生培养：2015年开始，共招收40人，25人已毕业（1名中国政府奖学金资助国际生；获得硕士博士研究生国家奖学金6人次；获得第一三共医药学奖学金1人次；获得辽宁省优秀毕业研究生1人，沈阳市优秀研究生1人次；获得校优秀研究生3人次；获得校优秀毕业研究生2人次，获得研究生学业奖学金多人次），升学2人。

研究生就业情况：均已就业，在大专院校及其附属医院、三甲医院、各级疾控中心等部门就业。

九、教材编写和期刊编委情况

教材/著作：

2017年：《Moyamoya Disease Explored Through RNF213: Genetics, Molecular Pathology, and Clinical Sciences》 Springer出版社编委

十、学会及其他学术团体任职情况

2020.12-2024.12 中国老年医学学会营养与食品安全分会委员

2020.11-至今中国营养学会营养与组学技术分会委员

2020.1-至今辽宁省营养学会第七、八届理事会理事

2018.5-2021.5 辽宁省环境科学学会环境与健康分会第一届理事会理事

2022.10-2026.10 辽宁省营养学会老年营养专业委员会常委

2022.10-2026.10 辽宁省营养学会营养与烹饪专业委员会常委

2018.12-2022.12 辽宁省营养学会第二届公共营养专业委员会委员