一、个人简介
尹智华，教授、博士生导师，流行病学教研室主任，辽宁省“百千万”人才工程万人层次，辽宁省高等学校创新人才支持计划获得者，第一批沈阳市高层次人才（拔尖人才）。
二、教育经历
1998-2003年：中国医科大学 预防医学 本科
2003-2006年：中国医科大学 流行病与卫生统计学 硕士
2008-2011年：中国医科大学 肿瘤学 博士
三、工作经历（包括博士后及出国进修经历）
2006-2008年：中国医科大学 公共卫生学院 流行病学教研室 助教
2008-2013年：中国医科大学 公共卫生学院 流行病学教研室 讲师
2013-2018年：中国医科大学 公共卫生学院 流行病学教研室 副教授
2017-2018：美国国立卫生研究院（NIH） 美国国家癌症研究所（NCI） 访问学者
2018年-今：中国医科大学 公共卫生学院 流行病学教研室 教授
四、研究方向
肿瘤流行病学
五、主持课题情况
辽宁省自然科学基金：外周血环状RNA表达及暴露环境危险因素与肺癌发生关系的分子流行病学研究。2021-2023年；5万元。
国家自然科学基金：基于前期GWAS的肺癌发生相关lncRNA基因SNP的筛选、验证及作用机制研究。2017-2020年；65万元。
辽宁省高等学校创新人才支持计划项目：肿瘤流行病学。2017-2019年；20万元。
辽宁省自然科学基金：lncRNA基因多态性及暴露环境危险因素与肺癌遗传易感性关系的分子流行病学研究。2016-2018年；5万元。
国家自然科学基金：MicroRNA基因单核苷酸多态性与肺癌遗传易感性的分子流行病学研究。2011-2014年；23万元。
六、获得科学技术奖情况
辽宁省科技进步一等奖：女性肺癌的危险度、预后因素及治疗方案评价的研究。2012年；第三完成人。
七、文章发表情况
1．Gao M, Cui Z, Li S, Li N, Tong L, Wang Y, Song M, Zhou B, Yin Z*. Survival Outcome and Clinicopathologicl analysis of Homeobox gene cluster-embedded LncRNAs in Human Cancers: A Systematic Review and Meta-analysis. Expert Review of Molecular Diagnostics. 2021 Sep 2;1-11. doi: 10.1080/14737159.2021.1970536.
2．Li N, Cui Z, Gao M, Li S, Song M, Wang Y, Tong L, Bi Y, Zhang Z, Wang S, Zhou B, Yin Z*. Genetic Polymorphisms of PRNCR1 and Lung Cancer Risk in Chinese Northeast Population: A Case-Control Study and Meta-Analysis. DNA Cell Biol. 2021 Jan;40(1):132-144.
3．Zhao Y, Ma S, Cui Z, Li S, Chen Y, Yin Y, Yin Z*. The relationship between LncRNAs and lung adenocarcinoma as well as their ceRNA network. Cancer Biomark. 2021 Apr 23. doi: 10.3233/CBM-203078.
4．Li N, Cui Z, Huang D, Gao M, Li S, Song M, Wang Y, Tong L, Yin Z*. Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: a meta-analysis based on 23478 subjects. Genomics. 2020, 112 (6): 4148-4154.
5．Li H, Cui Z, Lv X, Li J, Yang Z, Gao M, Bi Y, Zhang Z, Wang S, Li S, Zhou B, Yin Z*. Long non-coding RNA HOTAIR Function as a Competing Endogenous RNA for miR-149-5p to Promote the Cell Growth, Migration and Invasion in Non-small Cell Lung Cancer. Frontiers in oncology. 2020,10: 528520.
6．Li S, Cui Z, Zhao Y, Ma S, Sun Y, Li H, Gao M, Li N, Wang Y, Tong L, Song M, Yin Z*. Candidate lncRNA–microRNA–mRNA networks in predicting non-small cell lung cancer and related prognosis analysis. Journal of Cancer Research and Clinical Oncology. 2020, 146(4): 883-896.
7．Gao M, Li H, Bi Y, Zhang Z, Wang S, Li J, Yang Z, Lv X, Zhou B, Yin Z*. The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population. Journal of Cancer. 2020, 11 (3): 592-598.
8．Zhang Z, Li H, Li J, Lv X, Yang Z, Gao M, Bi Y, Wang S, Cui Z, Zhou B, Yin Z*. Polymorphisms in the PVT1 Gene and Susceptibility to the Lung Cancer in a Chinese Northeast Population: a Case-control Study. Journal of Cancer. 2020, 11 (3): 468-478.
9．Li N, Cui Z, Gao M, Li S, Song M, Wang Y, Tong L, Bi Y, Zhang Z, Wang S, Zhou B, Yin Z*. Genetic Polymorphisms of PRNCR1 and Lung Cancer Risk in Chinese Northeast Population: A Case-Control Study and Meta-Analysis. DNA Cell Biol. 2020 Nov 23. doi: 10.1089/dna.2020.6194.
10．Liu L, Wu W, Zhang S, Zhang K, Li J, Liu Yang, Yin Z*. Dental Caries Prediction Based on a Survey of the Oral Health Epidemiology among the Geriatric Residents of Liaoning, China. BioMed Research International. 2020.
11．Li N, Cui Z, Li S, Song M, Wang Y, Tong L, Gao M, Yin Z*. The Association Between Two Common Polymorphisms and Cancer Susceptibility: A Meta-Analysis. Journal of Surgical Research. 2020; Apr 29; 253: 156-166.
12．Bi Y, Cui Z, Li H, Lv X, Li J, Yang Z, Gao M, Zhang Z, Wang S, Zhou B, Yin Z*. Polymorphisms in Long Noncoding RNA-Prostate Cancer-Associated Transcript 1 Are Associated with Lung Cancer Susceptibility in a Northeastern Chinese Population. DNA and Cell Biology. 2019, 38(11): 1357-1365.
13．Lv X, Cui Z, Li H, Li J, Yang Z, Bi Y, Gao M, Zhang Z, Wang S, Zhou B, Yin Z*. Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population. Human Genomics. 2019; 13(1): 58.
14．Li J, Li H, Lv X, Yang Z, Gao M, Bi Y, Zhang Z, Wang S, Cui Z, Zhou B, Yin Z*. Diagnostic performance of circular RNAs in human cancers: A systematic review and meta-analysis. Molecular Genetics & Genomic Medicine. 2019 Jul;7(7):e00749.
15．Wang S, Cui Z, Li H, Li J, Lv X, Yang Z, Gao M, Bi Y, Zhang Z, Zhou B, Yin Z*. LncRNA NEAT1 polymorphisms and lung cancer susceptibility in a Chinese Northeast Han Population: A case-control study. Pathology Research and Practice. 2019 Dec;215(12):152723.
16．Li S, Li J, Li H, Gao M, Li N, Wang Y, Tong L, Song M, Yin Z*. Clinicopathological and prognostic significance of TINCR in caner: A meta-analysis. Pathology Research and Practice. 2019 Oct;215(10):152596.
17．Li H, Yang Z, Li J, Lv X, Gao M, Bi Y, Zhang Z, Wang S, Li S, Li N, Cui Z, Zhou B, Yin Z*. Genetic variants in lncRna HOTAIR are associated with lung cancer susceptibility in a Chinese han population in China:a case–control study. Cancer Management and Research. 2018, 10: 5209–5218.
18．Yin Z, Cui Z, Li H, Li J, Zhou B*. Polymorphisms in the H19 gene and the risk of lung Cancer among female never smokers in Shenyang, China. BMC Cancer. 2018 Sep 15;18(1):893.
19．Li J, Cui Z, Li H, Lv X, Gao M, Yang Z, Bi Y, Zhang Z, Wang S, Zhou B, Yin Z*. Clinicopathological and prognostic significance of long noncoding RNA MALAT1 in human cancers: a review and meta-analysis. Cancer Cell International. 2018 Aug 6;18:109.
20．Yang Z, Li H, Li J, Lv X, Gao M, Bi Y, Zhang Z, Wang S, Li S, Li N, Cui Z, Zhou B, Yin Z*. Association Between Long Noncoding RNA MEG3 Polymorphisms and Lung Cancer Susceptibility in Chinese Northeast Population. DNA Cell Biol. 2018;37(10):812-820.
21．Li J, Li H, Lv X, Yang Z, Gao M, Bi Y, Zhang Z, Wang S, Cui Z, Zhou B, Yin Z*. Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer. Cancer Cell International. 2018, 18: 91.
22．Lv X，Cui Z, Li H, Li J, Yang Z, Bi Y, Gao M, Zhou B, Yin Z*. Polymorphism in lncRNA AC008392.1 and its interaction with smoking on the risk of lung cancer in a Chinese population. Cancer Management and Research. 2018, 10: 1377-1387.
23．Gao M，Li H, Lv X，Zhou B, Yin Z*. Association Between Four Polymorphisms in lncRNA and Risk of Lung Cancer in a Chinese Never-Smoking Female Population. DNA and Cell Biology. 2018; 37(8):651-658.
24．Lv X，Cui Z, Yin Z*, Yang W, Li H, Zhou B. Effects of three common polymorphisms in microRNAs on lung cancer risk: a meta-analysis. Translational Cancer Research. 2018, 7(2): 371-382.
25．Li J, Cui Z, Li H, Lv X, Gao M, Yang Z, Bi Y, Zhou B, Yin Z*. Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis. Environmental Health and Preventive Medicine. 2018, 23(1):8.
26．Yin Z, Cui Z, Ren Y, Xia L, Wang Q, Zhang Y, He Q, Zhou B*. Association between polymorphisms in pre-miRNA genes and risk of lung cancer in a Chinese non-smoking female population. Lung cancer, 2016, 94: 15-21.
27．Yin Z, Cui Z, Li H, Ren Y, Qian B, Rothman N, Lan Q, Zhou B*. Polymorphisms in miR-135a-2, miR-219-2 and miR-211 as well as their interaction with cooking oil fume exposure on the risk of lung cancer in Chinese nonsmoking females: a case-control study. BMC Cancer. 2016, 16(1):751.
28．Li H, Ren Y, Xia L, Qu R, Kong L, Yin Z*, Zhou B*. Association of MicroRNA-149 Polymorphism with Lung Cancer Risk in Chinese Non-Smoking Female: A Case-Control Study. PLoS One. 2016, 11(9):e0163626.
29．Yin Z, Li H, Cui Z, Ren Y, Li X, Wu W, Guan P, Qian B, Rothman N, Lan Q, Zhou B*. Polymorphisms in pre-miRNA genes and cooking oil fume exposure as well as their interaction on the risk of lung cancer in Chinese non-smoking female population. OncoTargets and Therapy, 2016, 9: 395-401.
30．Yin Z, Cui Z, Li H, Zhou B*. The association between miR-146a polymorphism and cancer susceptibility: a meta-analysis. Int J Clin Exp Med, 2016, 9(6):9485-9494.
31．Hosgood HD 3rd#, Song M#, Hsiung CA#, Yin Z#, Shu XO#, Wang Z#, Chatterjee N, Zheng W, Caporaso N, Burdette L, Yeager M, Berndt SI, Landi MT, Chen CJ, Chang GC, Hsiao CF, Tsai YH, Chien LH, Chen KY, Huang MS, Su WC, Chen YM, Chen CH, Yang TY, Wang CL, Hung JY, Lin CC, Perng RP, Chen CY, Chen KC, Li YJ, Yu CJ, Chen YS, Chen YH, Tsai FY, Kim C, Seow WJ, Bassig BA, Wu W, Guan P, He Q, Gao YT, Cai Q, Chow WH, Xiang YB, Lin D, Wu C, Wu YL, Shin MH, Hong YC, Matsuo K, Chen K, Wong MP, Lu D, Jin L, Wang JC, Seow A, Wu T, Shen H, Fraumeni JF Jr, Yang PC, Chang IS, Zhou B, Chanock SJ, Rothman N, Lan Q. Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA). Hum Genet. 2015; 134(3):333-41.
32．Dong J, Hu Z, Wu C, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H*. Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet. 2012; 44(8):895-9.
33．Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, Guan P, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, Chen F, Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H*. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet. 2011; 43(8):792-6.
八、研究生培养情况
硕士招生：2014年开始，共招收31人，已毕业12人。
博士招生：2015年开始，共招收12人，已毕业2人。
九、学会及其他学术团体任职情况
2019-至今：中华预防医学会流行病学分会第六届委员会青年委员会 委员
2019-至今：中国抗癌协会癌症筛查与早诊早治专业委员会 委员
2019-至今：中国抗癌协会肿瘤流行病学青年委员会 委员
2021-至今：辽宁省预防医学会流行病与卫生统计学专业委员会 候任主委
2019-至今：辽宁省防痨协会第七届理事会 理事
十、获得奖励及荣誉称号情况
2021年：辽宁省第八届大学生优秀大创项目二等奖指导教师
2021年：第十五届挑战杯辽宁省大学生课外学术科技作品竞赛三等奖
2019年：中国医科大学优秀硕士学位论文指导教师
2018年：第一批沈阳市高层次人才（拔尖人才）
2016年：辽宁省高等学校创新人才支持计划获得者
2015年：辽宁省“百千万”人才工程万人层次
: zhyin@cmu.edu.cn
