一、个人简介

王园，教授、硕士研究生导师，尘肺研究室，沈阳市高层次人才（拔尖人才）。

二、教育经历

2004-2009年：中国医科大学 预防医学 本科

2009-2014年：中国医科大学 劳动卫生与环境卫生学 硕博连读

三、工作经历（包括博士后及出国进修经历）

2014-2019年：中国医科大学 公共卫生学院 尘肺研究室 讲师

2018-2019年：美国宾夕法尼亚州立大学 生物学系 访问学者

2019-2024年：中国医科大学 公共卫生学院 尘肺研究室 副教授

2025-至今：  中国医科大学 公共卫生学院 尘肺研究室 教授

四、研究方向

职业与环境神经毒理学

五、主持课题情况

1. 国家自然科学基金：妊娠期轻度碘营养不足及早期补碘对子代大鼠小脑运动性学习记忆的影响及机制研究。2016-2018年；18万。

2. 辽宁省自然科学基金：妊娠期和哺乳期母体拟除虫菊酯暴露对子代神经发育的影响及机制研究。2020-2023年；5万。

六、获得科学技术奖情况

1．辽宁省科技进步奖三等奖：脑发育关键期不同摄碘量对脑神经发育及智力影响的应用基础研究。2016年；第四完成人。

七、文章发表情况

1. Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wang*. Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring. Ecotoxicology and Environmental Safety. 2024, 274: 116196.

2. Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wang*. Effects of pyrethroids on the cerebellum and related mechanisms: a narrative review. Crit Rev Toxicol. 2023, 53(4): 229-243.

3. Yuan Wang, Jun Han, Xi Chen, Xinning Zeng, Yi Wang, Jing Dong, Jie Chen*. Maternal iodine supplementation improves motor coordination in offspring by modulating the mGluR1 signaling pathway in mild iodine deficiency-induced hypothyroxinemia rats. Journal of Nutritional Biochemistry. 2018, 58: 80-89.

4. Yuan Wang, Jing Dong, Yi Wang, Wei Wei, Binbin Song, Zhongyan Shan, Weiping Teng, Jie Chen*. Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel fiber–Purkinje cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex. 2016, 173(2): 465-74.

5.Yuan Wang, Yi Wang, Jing Dong, Wei Wei, Binbin Song, Hui Min, Ye Yu, Xibing Lei, Ming Zhao, Weiping Teng*, Jie Chen*. Developmental Hypothyroxinemia and Hypothyroidism Reduce Proliferation of Cerebellar Granule Neuron Precursors in Rat Offspring by Downregulation of the Sonic Hedgehog Signaling Pathway. Molecular Neurobiology. 2014, 49(3):1143-1152.

6. Yuan Wang#, Yi Wang #, Jing Dong, Wei Wei, Binbin Song, Hui Min, Weiping Teng*, Jie Chen*. Developmental hypothyroxinaemia and hypothyroidism limit dendritic growth of cerebellar Purkinje cells in rat offspring: involvement of microtubule-associated protein 2 (MAP2) and stathmin. Neuropathology and Applied Neurobiology. 2014, 40(4):398-415.

7. Ye Yu#, Yuan Wang#, Yi Wang, Jing Dong, Hui Min, Jie Chen*. Maternal marginal iodine deficiency delays cerebellar Bergmannglial cell development in rat offspring: Involvement of Notch signaling pathway. Neurotoxicology. 2018, 68: 159-166.

8. Jing Dong, Yuan Wang, Yi Wang, Wei Wei, Hui Min, Binbin Song, Qi Xi, Weiping Teng, Jie Chen*. Iodine deficiency increases apoptosis and decreases synaptotagmin-1 and PSD-95 in rat hippocampus. Nutritional Neuroscience, 2013, 16(3):135-141.

9. Jing Dong, Heling Song, Yuan Wang, Min Li, Ye Yu, Yi Wang, Jie Chen*. Maternal Different Degrees of Iodine Deficiency during Pregnant and Lactation Impair the Development of Cerebellar Pinceau in Offspring. Front Neurosci. 2017, 11: 298.

10. Ye Yu, Jing Dong, Yuan Wang, Yi Wang, Hui Min, Zhongyan Shan, Weiping Teng, Jie Chen*. Maternal Marginal Iodine Deficiency Limits Dendritic Growth of Cerebellar Purkinje Cells in Rat Offspring by NF-jB Signaling and MAP1B. Environ Toxicol. 2017, 32(4):1241-1251.

11. Hui Min, Jing Dong, Yi Wang, Yuan Wang, Ye Yu, Zhongyan Shan, Qi Xi, Weiping Teng, Jie Chen*. Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton. Molecular Neurobiology, 2017, 54(1): 437-449.

12. Hui Min, Yi Wang, Jing Dong, Yuan Wang, Ye Yu, Zhongyan Shan, Qi Xi, Weiping Teng, Jie Chen*. Effects of Maternal Marginal Iodine Deficiency on Dendritic Morphology in the Hippocampal CA1 Pyramidal Neurons in Rat Offspring. Neuromolecular Med, 2016,18(2): 203-215.

13. Hui Min, Jing Dong, Yi Wang, Yuan Wang, Weiping Teng, Qi Xi, Jie Chen*. Maternal Hypothyroxinemia-induced Neurodevelopmental Impairments in the Progeny. Molecular Neurobiology, 2016, 53(3):1613-1624.

14. Jing Dong, Xibing Lei, Yi Wang, Yuan Wang, Heling Song, Min Li, Hui Min, Ye Yu, Qi Xi, Weiping Teng, Jie Chen*. Different Degrees of Iodine Deficiency Inhibit Differentiation of Cerebellar Granular Cells in Rat Offspring, via BMP-Smad1/5/8 Signaling.Molecular Neurobiology, 2016, 53 (7): 4606-4617.

八、研究生培养情况

硕士生培养：2020年始，共招收9人。

九、获得奖励及荣誉称号情况

2023年：荣获中国医科大学“优秀硕士学位论文”指导教师

2023年：指导大学生创新创业项目省级1项

：yuanwang@cmu.edu.cn