一、个人简介
张廷剑，男，药物化学硕士，药理学博士，副教授，博士研究生导师；招生专业：药物化学（学硕、博士），药学（专硕）；主持国家自然科学基金项目2项，辽宁省教育厅/科技厅项目2项，中国医科大学青年英才项目1项，中国医科大学青年骨干人才项目1项；在Eur J Med Chem, J Med Chem, Bioorg Chem, Dyes and Pigments等药物化学/化学杂志上发表研究论文40余篇；获批发明专利10余项；副主编清华大学出版社《新编中药成分学》1部及上海科学技术出版社《药物化学》教材1部；为Bioorg Chem, Redox Biol, Food Biosci, Expert Opin Ther Pat 等期刊审稿人。
Email: tjzhang@cmu.edu.cn
通讯地址：沈阳市沈北新区蒲河路77号，中国医科大学，药学院楼238室，110122
二、研究方向
1．小分子抗痛风药物的设计合成与开发
2．小分子抗肿瘤药物的设计合成
3．小分子生物荧光探针的设计合成
4．计算机辅助药物设计
三、科研课题
1．国家自然科学基金面上项目，82273785，52万，2023.01-2026.12，主持人
2．辽宁省科技厅支持中国医科大学高质量发展资金项目，10万，2022.09-2023.08，主持人
3．国家自然科学基金青年项目，81803355，21万，2019.01-2021.12，主持人
4．辽宁省高等学校青年计划，LQNK201739，5万，2018.01-2020.12，主持人
四、人才称号
1．2022年，中国医科大学高层次人才青年骨干人才
2．2021年，中国医科大学青年英才（A层次）
五、发表论文（近五年，*为通讯作者）
1. Wang, Z. R.; Zhang, T. J.; Wang, Q. Y.; Xu, E. Y.; Zhang, X.; Zhang, Z. H.; Lu, P. F.; Zhao, H. Y.; Wang, L.*; Meng, F. H.*, (E)-2-styrylanthracene-9,10-dione derivatives as novel fluorescent probes: synthesis, photophysical properties and application in mitochondria imaging. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2023, 286, 121988.
2. Hu, S.-s.; Zhang, T.-j.; Wang, Z.-r.; Xu, E.-y.; Wang, Q.-y.; Zhang, X.; Guo, S.; Ge, G.-h.; Wang, J.; Meng, F.-h.*, Design, synthesis and structure-activity relationship of N-phenyl aromatic amide derivatives as novel xanthine oxidase inhibitors. Bioorg. Chem. 2023, 133, 106403.
3. Zhao, J.; Zhang, B.; Mao, Q.; Ping, K.; Zhang, P.; Lin, F.; Liu, D.; Feng, Y.; Sun, M.; Zhang, Y.; Li, Q. H.; Zhang, T.*; Mou, Y.*; Wang, S.*, Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA–PABA–MAC and 5-ASA–PABA–Diamine for the Treatment of Ulcerative Colitis. J. Med. Chem. 2022, 65, 4926-4948.
4. Zhao, J.; Mao, Q.; Lin, F.; Zhang, B.; Sun, M.; Zhang, T. *; Wang, S.*, Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur. J. Med. Chem. 2022, 229, 114086.
5. Zhang, T.-j.; Zhang, Z.-h.; Zhang, X.; Wang, Z.-r.; Xu, E.-y.; Tu, S.; Zhang, Y.; Meng, F.-h. *, Design, synthesis and biological evaluation of N-(4-alkoxy-3-(1H-tetrazol-1-yl)phenyl) heterocyclic aromatic amide derivatives as xanthine oxidase inhibitors. Bioorg. Chem. 2022, 127, 105938.
6. Zhang, T.-j.; Zhang, X.; Xu, E.-y.; Wang, Z.-r.; Zhang, Z.-h.; Wang, Q.-y.; Wang, L.; Wen, Y.-q.; Meng, F.-h.*, A possible covalent xanthine oxidase inhibitor TS10: inhibition mechanism, metabolites identification and PDPK assessment. Bioorg. Chem. 2022, 128, 106064.
7. Zhang, T.-j.; Zhang, Y.; Zhang, Z.-h.; Wang, Z.-r.; Zhang, X.; Hu, S.-s.; Lu, P.-f.; Guo, S.; Meng, F.-h.*, Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xan- thine oxidase inhibitors. Bioorg. Med. Chem. Lett. 2022, 60, 128582.
8. Zhang, Y.; Zhang, T.-j.; Li, X.-y.; Liang, J.-w.; Tu, S.; Xu, H.-l.; Xue, W.-h.; Qian, X.-h.; Zhang, Z.-h.; Zhang, X.; Meng, F.-h.*, 2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1] octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents. Eur. J. Med. Chem. 2021, 210, 112988.
9. Zhang, X.; Zhang, T.-j.; Wang, Z.-r.; Wang, Q.-y.; Lu, P.-f.; Zhao, H.-y.; Wang, L.; Meng, F.-h.*, (E)-2-Styrylanthracene-9,10-dione: A new type of fluorescent probe core and its application in specific mitochondria imaging. Dyes and Pigments 2021, 196, 109797.
10. Zhang, T.-j.; Tu, S.; Zhang, X.; Wang, Q.-y.; Hu, S.-s.; Zhang, Y.; Zhang, Z.-h.; Wang, Z.-r.; Meng, F.-h.*, Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation. Bioorg. Chem. 2021, 117, 105417.
11. Tu, S.; Zhang, T.-j.; Zhang, Y.; Zhang, X.; Zhang, Z.-h.; Meng, F.-h.*, N-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors. Bioorg. Chem. 2021, 115, 105181.
12. Zhang, T.-j.; Zhang, Y.; Tu, S.; Wu, Y.-h.; Zhang, Z.-h.; Meng, F.-h.*, Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors. Eur. J. Med. Chem. 2019, 183, 111717.
