个人简介：

王桂玲,女，现为中国医科大学生命科学学院，省部共建医学细胞生物学重点实验室，分子细胞生物学教研室教授，博士生导师，博士后导师，三级教授，沈阳市拔尖人才。2016-2018年在美国新泽西肿瘤研究所从事细胞代谢异常与肺癌等研究工作。曾获得“辽宁省高等学校优秀青年骨干教师”荣誉称号；辽宁省硕士优秀毕业论文指导教师。主持承担三项国家自然科学基金项目及三项辽宁省科研项目课题等。曾获得辽宁省科学技术二等奖及辽宁省自然科学学术成果奖二等奖。从2019年至今，以通讯作者身份在Cell Death & Differentiation、Cell Death & Desease、Materials Today Bio及Chinese Chemical Letters等国际期刊发表中科院1区11篇，2区4篇论文。培养的研究生曾现获得辽宁省硕士优秀毕业学术论文，辽宁省优秀毕业生，国家奖学金及沈阳市优秀研究生等称号。

研究方向肿瘤相关基因信号调控网络，细胞代谢异常与肿瘤，医工结合与肿瘤治疗等。

联系方式：glingwang@cmu.edu.cn

研究成果（近五年以通讯作者发表的文章）：

1.MORC2 regulatesC/EBPα-mediated cell differentiation via sumoylation. Cell Death Differ. 2019Oct;26(10):1905-1917.

2.MORC protein family-related signature within human disease and cancer. Cell Death Dis. 2021 Nov 27;12(12):1112.

3.Attachment of -tBu groupsto aza-BODIPY core at 3,5-sites with ultra-large Stokes shift to enhancephotothermal therapy through apoptosis mechanism.Mater Today Bio. 2022 Sep29;16:100446.

4.Combination ofniclosamide and current therapies to overcome resistance for cancer: Newfrontiers for an old drug.Biomed Pharmacother. 2022 Nov;155:113789

5.Niclosamide as a Promising Therapeutic Player in HumanCancer and Other Diseases. Int J Mol Sci. 2022 Dec 17;23(24):16116.

6.Synthesis of aza-BODIPYs withbarrier-free rotation of the -tBu group at 3-site and enhancement ofphotothermal therapy by triggering cancer cell apoptosis.J Mater Chem B. 2022 Oct26;10(41):8443-8449.

7.Engineering J-aggregates for NIR-induced meso-CF3-BODIPY nanoparticles byactivated apoptosis mechanism in photothermal therapy. Chinese Chemical Letters，2023, September,34(9)

8.Constructionof diene-extended meso-CF3-BODIPY for spectroscopic study and photothermalexploration，Dyes and Pigments, 2023,6

9.Development of functional dye with redshifted absorption based on Knoevenagelcondensation at 1-site in phenyl[b]-fused BODIPY. Chinese Chemical Letters.online 28 July 2023

10.Oncogenic MORC2 in Cancer Development and Beyond，Genes&Diseases. 2023,11(2):861-873.

11.Aza-BODIPY with two efficacious fragments for NIR light-driven photothermal therapy by triggering cancer cell apoptosis.J Mater Chem B. 2023 Nov 15;11(44):10625-10631.

12.Heavy-atom-free orthogonal configurative dye 1,7-di-anthra-aza-BODIPY for singlet oxygen generation. Chinese Chemical Letters. online22 December 2023

13.YTHDF1 in Tumor Cell Metabolism: An Updated Review.Molecules,2023 Dec 26;29(1):140

14.Unlocking the adenosine receptor mechanism of the tumour immune microenvironment.Frontiers in Immunology,2024 Jun 27:15:1434118.

15.tert-Butyl substituted aza-BODIPY-based bromides for phototherapy.Dyes and Pigments,online 10 May 2024 .

科研项目：

1.国家自然科学基金项目（30871294，81572611，81828009）

2.辽宁省科技厅应用基础项目（2023JH2/101300012）

3.辽宁省教育厅项目（LJKMZ20221205）