个人简介：

陈誉华，教授，博士生导师。现任国家卫生健康委细胞生物学重点实验室暨教育部医学细胞生物学重点实验室主任，教育部基础医学教学指导委员会委员，中国细胞生物学学会资深理事。曾任中国医科大学基础医学院和生命科学学院院长、中华医学会医学细胞生物学分会主任委员、中国细胞生物学会常务理事兼医学细胞生物学分会副会长。主要从事“脑微血管稳态调控机制与神经退行性疾病”领域研究工作。先后获13项国家自然科学基金资助，发表SCI论文70余篇，包括Nature Communications、Journal of Cell Biology、Cell Reports、J Immunol、J Biol Chem等期刊通讯作者论文。主编本科生国家级规划教材《医学细胞生物学》（4-7版），副主编八年制国家级规划教材《细胞生物学》（3-4版），主讲的《发育生物学与再生医学》入选国家一流课程。先后获教育部科技进步一等奖，入选教育部跨世纪人才，获国务院政府特殊津贴，辽宁省特聘教授和教学名师。

联系方式：yhchen@cmu.edu.cn

研究成果：

1.Zhao YH, Liang Y, Wang KJ, Jin SN, Yu XM, Zhang Q, Wei JY, Liu H, Fang WG, Zhao WD, Li Y,Chen YH*. Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity.J Cereb Blood Flow Metab.2024, 25:271678X241248907.

2. Li Q, Li B, Liu L, Wang KJ, Liu MY, Deng Y, Li Z, Zhao WD, Wu LY,Chen YH*, Zhang K. Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease.J Neuroinflammation. 2024, 21(1):125.

3.Liu H, Wei JY, Li Y, Ban M, Sun Q, Wang HJ, Zhao D, Tong PG, Wang L, Wang KJ, Yue JL, Zhang HY, Fang WG, Liu DX, Shang DS, Li B, Jin YP, Cao L, Zhao WD,Chen YH*. Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.J Cell Biol. 2023，222(5):e202103098.

4. Li Y, Wei JY, Liu H, Wang KJ, Jin SN, Su ZK, Wang HJ, Shi JX, Li B, Shang DS, Fang WG, Qin XX, Zhao WD,Chen YH*. An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity.Cell Rep. 2022, 39(2):110656.

5. Zhang SH, Liu DX, Wang L, Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, Li B, Han XN, Zhao WD,Chen YH*.A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells.J Biol Chem. 2019, 294(16):6375-6386.

6. Zhao WD, Liu DX, Wei JY, Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, Li QC, Cao L, Kim KS,Chen YH*.Caspr1 is a host receptor for meningitis-causing Escherichia coli.Nat Commun. 2018, 9(1):2296.

7.Zhang H, Zhang S, Zhang J, Liu D, Wei J, Fang W, Zhao W,Chen Y*, Shang D. ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells.J Cereb Blood Flow Metab. 2018,38(5):809-822.

8．Shang DS,Yang YM,Zhang H,Tian L,Jiang JS,Dong YB,Zhang K,Li B,Zhao WD,Fang WG,Chen YH*. Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice.J Cereb Blood Flow Metab.2016, 36(11):1978-1991.

9.Tian L,Zhang K,Tian ZY,Wang T,Shang DS,Li B,Liu DX,Fang WG,Wang ZY,Chen YH*. Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-β in Alzheimer's disease.J Alzheimers Dis.2014, 42(2):511-20.

10.Li B, Wang C, Zhang Y, Zhao XY, Huang B, Wu PF, Li Q, Li H, Liu YS, Cao LY, Dai WM, Fang WG, Shang DS, Cao L, Zhao WD,Chen YH*. Elevated PLGF contributes to small cell lung cancer brain metastasis.Oncogene. 2013, 32(24):2952-62.

11. Zhao WD, Liu W, Fang WG, Kim KS,Chen YH*. Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through PI3K/Akt signaling pathway.Infect Immun, 2010, 78(11): 4809-4816.

12. Liu YJ, Guo DW, Tian L, Shang DS, Zhao WD, Li B, Fang WG, Zhu L,Chen YH*. Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent.Neurobiol Aging，2010，31(2):175-88.

13. Li M, Shang DS, Zhao WD, Tian L, Li B, Fang WG, Zhu L, Man SM,Chen YH*. Amyloid β interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier.J Immunol, 2009, 182(9): 5778-5788. Selected by F1000 Prime

14.Man SM, Ma YR, Shang DS, Zhao WD, Li B, Guo DW, Fang WG, Zhu L,Chen YH*.Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease.Neurobiol Aging. 2007, 28(4):485-96.

15. Li B, Zhao WD, Tan ZM, Fang WG, Zhu L,Chen YH*. Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells.FEBS Lett, 2006, 580(17):4252-4260. Selected by F1000 Prime

科研项目：

1.国家自然科学基金面上项目“膜整合蛋白Itm2a通过胞膜窖调控血脑屏障转胞吞效率的机制及其在脑微血管衰老中的作用”,2025.01 - 2028.12.

2.国家自然科学基金面上项目“Caspr3与Notch1互作维持脑微血管生成和抑制脑微血管退化的机制”，2022.01 - 2025.12.

3.国家自然科学基金面上项目“Caspr与ATP1B3互作调控钠钾泵装配和维持神经血管单元功能的机制”,2018.01 - 2021.12.