发育细胞生物学教研室
赵伟东

undefined个人简介:

赵伟东,教授,博士生导师,国家级高层次青年人才,现任中国医科大学生命科学学院院长,发育细胞生物学教研室主任。2011-2016年曾在美国国立卫生研究院从事研究工作。赵伟东课题组的研究方向为:脑微血管稳态与脑疾病,主要关注脑微血管和神经微血管单元的稳态维系机制,及其与疾病(包括脑卒中、阿尔茨海默病、糖尿病等)发生发展的关系。曾在Nature、Circulation Research、Nature Communications、J Cell Biol、Alzheimers Dement、Cell Reports等期刊上发表第一/通讯作者研究论文,先后主持国家自然科学基金6项,包括区域联合基金重点项目1项。现为全国高等学校临床医学专业规划教材《医学细胞生物学》(第7版,人民卫生出版社)数字主编,兼任中华医学会医学细胞生物学分会副主任委员。

联系方式:wdzhao@163.com

代表性论文(*通讯作者):

1.Li ZJ, Yang Z, Zhao D, Qiu YH, Wan WY, Huang ZK, Tian L, Qi RQ, Liu HG, Chen YH, Min DY, Xu XQ*,Zhao WD*.Circulatory pro-CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice.Alzheimers Dement.2026 May;22(5):e71494.(中科院1区,影响因子11.1)

2.Zhao D, Huang ZK, Liang Y, Li ZJ, Zhang XW, Li KH, Wu H, Zhang XD, Li CS, An D, Sun X, An MX, Shi JX, Bao YJ, Tian L, Wang DF, Wu AH, Chen YH,Zhao WD*. Monocytes release pro-cathepsin D to drive blood-to-brain transcytosis in diabetes.Circ Res. 2024 Mar 29;134(7):e17-e33.(中科院1区,影响因子16.5)

3.Yang JL, Sun X, Shi JX, Cui QX, Cao XY, Wang KT, An MX, Wu SJ, Yang YL*,Sun HZ*,Zhao WD*.Calmodulin triggers activity-dependent rRNA biogenesis via interaction with DDX21.J Neurosci.2024 Jul 26:e1841232024.(中科院2区,影响因子4.4)

4.Zhang XW, An MX, Huang ZK, Ma L, Zhao D, Yang Z, Shi JX, Liu DX, Li Q, Wu AH, Chen YH,Zhao WD*.Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.Redox Biol.2023 Feb;59:102588.(中科院1区,影响因子11.4)

5.Liu H, Wei JY, Li Y, Ban M, Sun Q, Wang HJ, Zhao D, Tong PG, Wang L, Wang KJ, Yue JL, Zhang HY, Fang WG, Liu DX, Shang DS, Li B, Jin YP*, Cao L*,Zhao WD*,Chen YH*. Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.J Cell Biol.2023 May 1;222(5):e202103098.(中科院1区,影响因子7.8)

6.Li Y, Wei JY, Liu H, Wang KJ, Jin SN, Su ZK, Wang HJ, Shi JX, Li B, Shang DS, Fang WG, Qin XX,Zhao WD*,Chen YH*. An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity.Cell Rep.2022 Apr 12;39(2):110656.(中科院1区,影响因子8.8)

7.Zhao WD*,Liu DX, Wei JY, Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, Li QC, Cao L, Kim KS, Chen YH*. Caspr1 is a host receptor for meningitis-causing Escherichia coli.Nat Commun.2018 Jun 12;9(1):2296.(中科院1区,影响因子11.878)

8.Zhao WD,Hamid E, Shin W, Wen PJ, Krystofiak ES, Villarreal SA, Chiang HC, Kachar B, Wu LG*. Hemi-fused structure mediates and controls fusion and fission in live cells.Nature. 2016 Jun 23;534(7608):548-52.(中科院1区,影响因子40.137)