个人简介：
赵越，中国医科大学生命科学学院，副院长,教授，博导。染色质生物学研究室主任。
2003年获日本九州大学脏器机能内科学博士学位；2003.04-2008.08期间日本东京大学分子细胞生物学研究所博士后；2008年回国，任职于中国医科大学生命科学学院，染色质生物学研究室主任。主要从事性激素受体介导基因转录调控的表观遗传学机制的研究，近年来围绕性激素受体介导的基因转录调控的新辅调节因子的筛选和鉴定及其在相关肿瘤中的生物学功能展开研究，取得了多项创新性发现。
主要研究方向是：（1）新基因的筛选、鉴定和功能分析；（2）核受体介导的基因转录的调控；（3）核受体辅助调节因子在性激素相关肿瘤等疾病发生发展中的作用及其分子机制。以第一作者和通讯作者在国际知名杂志发表论文多篇，包括Molecular Cell，EMBO Molecular Medicine, Nucleic Acids Research，Cell Death &Differentiation, JBC等。获国家自然科学基金面上项目6项，973项目子课题，教育部科学计划项目等资助。辽宁省特聘教授，辽宁省百千万人才“百层次”，是中国细胞生物学学会青委会委员，获全国归侨侨眷先进个人等称号，辽宁省省（部）属高校党代表，市政协委员。
联系方式：yzhao30@cmu.edu.cn
研究成果：
1）Ruina Luan, Mingcong He , Hao Li, Yu Bai, Anqi Wang, Ge Sun, Baosheng Zhou, Manlin Wang, Chunyu Wang, Shengli Wang, Kai Zeng, Jianwei Feng, Lin Lin, Yuntao Wei, Shigeaki Kato, Qiang Zhang* & Yue Zhao*. MYSM1 acts as a novel co-activator of ERa to confer antiestrogen resistance in breast cancer.
EMBO Molecular Medicine. 2023, 16:10-39.中科院1区(IF=11.1)
2）Kai Zeng, Weiwen Xie, Chunyu Wang, Shengli Wang, Wei Liu, Yingjie Su, Lin Lin, Renlong Zou, Ge Sun, Baosheng Zhou, Manlin Wang, Ruina Luan, Yu Bai, Yunlong Huo, Shigeaki Kato, Xinping Zhong*, Yue Zhao*. USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.
Cell Death & Disease, 2023, 14: 194.中科院1区 (2021 IF=9.685)
3) Wei Liu; Shengi Wang; Linlin; Renlong Zou; Hongmiao Sun; Kai Zeng; Yi Wu; Yiling Li; Shigeaki Kato; Xiuxia Wang*; Chunyu Wang*; Yue Zhao*. BAP18 acting as a novel peroxisome proliferator-activated receptor αco-regulator contributes to hepatocellular carcinoma progression.
BBA - Molecular Basis of Disease, 2023, 1870: 166974.中科院2区（IF=6.2）
4) Ge Sun, Yuntao Wei , Baosheng Zhou, Manlin Wang, Ruina Luan, Yu Bai, Hao Li, Shan Wang, Dantong Zheng, Chunyu Wang, Shengli Wang, Kai Zeng, Shuchang Liu, Lin Lin, Mingcong He, Qiang Zhang and Yue Zhao*. BAP18 facilitates CTCF-mediated chromatin accessible to regulate enhancer activity in breast cancer.
Cell Death & Differentiation, 2023, 30(5): 1260-1278.中科院1区(2021 IF: 12.067)
5) Yingjie Su, Kai Zeng, Shuchang Liu, Yi Wu, Chunyu Wang, Shengli Wang, Lin Lin, Renlong Zou, Ge Sun, Ruina Luan, Baosheng Zhou, Yu Bai, Jumin Niu, Yi Zhang*, Yue Zhao*. Ubiquitin-specific peptidase 14 maintains estrogen receptor α stability via its deubiquitination activity in endometrial cancer.
Journal of Biological Chemistry, 2023; 299 (1), 102734.中科院2区(2022, IF=5.486)
6) Tingting Zhou, Shengli Wang, Xiaoyu Song, Wensu Liu, Fang Dong, Yunlong Huo, Renlong Zou, Chunyu Wang, Siyi Zhang, Wei Liu, Ge Sun, Lin Lin, Kai Zeng, Xiang Dong, Qiqiang Guo, Fei Yi, Zhuo Wang, Xiaoman Li, Bo Jiang, Liu Cao*, Yue Zhao* RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
Cell Death &Disease. 2022;13:352.中科院1区(IF=9.685)
7) Zining Jin, Qingfu Zhang, Chunyu Wang, Shengli Wang, Lin Lin, Renlong Zou, Ge Sun, Kai Zeng, Baosheng Zhou, Yuxin Tong, Bo Chen, Yue Zhao*
High phosphorylatedcyclin-dependent kinase 2 expression indicates poor prognosis of luminal androgen receptor triple-negative breast cancer.
Acta Biochimica et Biophysica Sinica 2022; 54(7): 1034–1038 (IF 3.848)
8) Shan Wei, Wei Liu, Ning Sun, Yi Wu, Huijuan Song, Chunyu Wang, Shengli Wang, Renlong Zou, Lin Lin, Kai Zeng, Baosheng Zhou, Manlin Wang, Ruina Luan, Fan Yang, Yue Zhao*. MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma.
Cancer Science. 2021;112(5):1865-1877.中科院2区(2020 IF= 6.716)
9) Tianyu Tang, Jiao Jiao, Da Li, Ge Sun, Lin Lin, Chunyu Wang, Shengli Wang, Renlong Zou, Wensu Liu, Yue Zhao*, Xiuxia Wang*. The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.
Molecular Cellular Endocrinology. 2021; 527:111228.中科院2区(2020 IF=4.102)
10) Wei Liu, Chunyu Wang, Shengli Wang, Kai Zeng, Shan Wei, Ning Sun, Ge Sun, Manlin Wang, Renlong Zou, Wensu Liu, Lin Lin, Huijuan Song, Zining Jin, and Yue Zhao*. PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
International Journal of Biological Sciences. 2021, 17(1):188-203. (2021 IF: 10.75)
11) Ning Sun, Xinping Zhong, Shengli Wang, Kai Zeng, Hongmiao Sun, Ge Sun, Renlong Zou,Wei Liu, Wensu Liu, Lin Lin, Huijuan Song, Chi Lv, Chunyu Wang*, and Yue Zhao*. ATXN7L3 positively regulates SMAD7 transcription in hepatocellular carcinoma with growth inhibitory function.
EBioMedicine. 2020; 62:103108. (2020 IF: 8.143)
12) Ge Sun, Chunyu Wang, Shengli Wang, Hongmiao Sun, Kai Zeng, Renlong Zou,
Lin Lin, Wei Liu, Ning Sun, Huijuan Song, Wensu Liu, Tingting Zhou, Feng Jin,
Zhongyan Shan, and Yue Zhao*. An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core subunits co-activates ERα action and associates with the sensitivity of antiestrogen in breast cancer.
Nucleic Acids Research. 2020;48(19):10768-10784. (2020 IF:16.971)
13) Huijuan Song, Ning Sun, Lin Lin, Shan Wei, Kai Zeng, Wei Liu, Chunyu Wang, Xinping Zhong, Manlin Wang, Shengli Wang, Baosheng Zhou, Chi Lv, Wensu Liu, and Yue Zhao*. Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.
Cancer Science. 2020;111(10):3665-3678. (2020 IF: 6.716)
14) Xue Wang, Chunyu Wang, Guangqi Yan, Yuanyuan Kang, Ge Sun, Shengli Wang, Renlong Zou, Hongmiao Sun, Kai Zeng, Huijuan Song, Wei Liu, Ning Sun, Wensu Liu, and Yue Zhao*. BAP18 is involved in upregulation of CCND1/2 transcription to promote cell growth in oral squamous cell carcinoma.
EBioMedicine. 2020; 53:102685. (2020 IF: 8.143)
15) Kai Zeng, Yi Wu, Chunyu Wang, Shengli Wang, Hongmiao Sun, Renglong Zou, Ge Sun, Huijuan Song, Wei Liu, Ning Sun, Shan Wei, Wensu Liu, Yingjie Sun, Tingting Zhou, Yi Zhang*, and Yue Zhao*. ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription.
Cancer Science. 2020;111(6):2062-2077. (2020 IF: 6.716)
16) Shengli Wang#, Xinping Zhong#, Chunyu Wang, Hao Luo, Lin Lin, Hongmiao Sun, Ge Sun, Kai Zeng, Renlong Zou, Wei Liu, Ning Sun, Huijuan Song, Wensu Liu, Qiang Zhang, Zhixuan Liao, Xiaochun Teng, Tingting Zhou, Xun Sun, and Yue Zhao*. USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer.
Cell Death & Differentiation. 2020;27(11):3131-3145. (2020 IF: 15.828)
17) Yi Wu, Kai Zeng, Chunyu Wang, Shengli Wang, Hongmiao Sun, Wensu Liu, Xiuxia Wang, Jumin Niu, Shu-yan Cong, Xin Zhou, and Yue Zhao*. Histone Acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ERα stability.
BBRC, 2019;509(2):541-548. (IF:2.705)
18) Shengli Wang#, Hao Luo#, Chunyu Wang, Hongmiao Sun, Ge Sun, Ning Sun, Kai Zeng, Renlong Zou, Rijiao Cong, Lei Yang, Da Li, Xin Zhou, Xinping Zhong, Lin Lin, Jiao Jiao, Guangqi Yan, Xue Wang, Liu Cao, and Yue Zhao*. RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer.
BBA-Molecular Basis of Disease, 2017; 1863: 1615-1628. (IF: 5.108)
19) Shiying Sun, Xinping Zhong, Chunyu Wang, Hongmiao Sun, Shengli Wang, Tingting Zhou, Renlong Zou, Lin Lin, Ning Sun, Ge Sun, Liu Cao, and Yue Zhao*. BAP18 carrying a SANT domain coactivates androgen receptor action and promotes prostate cancer progression.
Nucleic Acids Research. 2016; 44(17): 8112-8128. (IF: 10.162)
20) Chunyu Wang, Hongmiao Sun, RenlongZou, Tingting Zhou, Shengli Wang, Shiying Sun, Changci Tong, HaoLuo, Yanshu Li, Zhenhua Li, Enhua Wang,Yuhua Chen, Liu Cao, Feng Li, and Yue Zhao*. MDC1 functionally identified as an androgen receptorco-activator participates in suppression of prostate cancer.
Nucleic Acids Research. 2015; 43(10): 4893-908. (IF: 9.202)
21) RenlongZou#, XinpingZhong#, Chunyu Wang, Hongmiao Sun, Shengli Wang, Lin Lin, Shiying Sun, Changci Tong, HaoLuo, PengGao, Yanshu Li, Tingting Zhou, Da Li, Liu Cao, and Yue Zhao*. MDC1 enhances estrogen receptor-mediated transactivation and contributes to breast cancer suppression.
International Journal of Biological Sciences. 2015; 11(9): 992-1005. (IF: 3.982)
22) Tingting Zhou#, Shuyan Cong#, Shiying Sun, Hongmiao Sun, RenlongZou, Shengli Wang, Chunyu Wang, Yue Zhao*. Identification of endocrine disrupting chemicals activating SXR-mediated transactivation of CYP3A and CYP7A1.
Molecular and Cellular Endocrinology. 2013; 365(1): 36-43. (IF: 4.19)
23) Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavie Le Guezennec, Hendrik G Stunnenberg, Aleksey Krasnov, Sofia Georgieva, Roland Schule, Ken-Ichi Takeyama, Shigeaki Kato, Laszlo Tora*, Didier Devys*. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
Mol. Cell. 2008; 29(1): 92-101. (IF: 14.608)
24) Yue Zhao, Ken-ichi Takeyama, Shun Sawatusbashi, Saya Ito, Eriko Suzuki, Kaoru Yamagata, Yuko Shirode, Masahiko Tanabe, Feng Li, Shuhei Kimura, Alexander Kouzmenko, Testuya Tabata and Shigeaki Kato. Co-repressive function of CBP for Androgen Receptor in pericentric heterochromatin in a Drosophila experimental model system
Mol. Cell. Biol.，2009, 29(4): 1017-1034. (IF: 6.238)
25) Yue Zhao, Kiminobu Goto, Masayuki Saitoh, Toshihiko Yanase, Masatoshi Nomura, Taijiro Okabe, Ryoichi Takayanagi, Hajime Nawata. Activation Function-1 domain of Androgen Receptor Contribute to the Interaction between Subnuclear Splicing Factor Compartment and Nuclear Receptor Compartment.
J Biol. Chem. 2002; 277 (33): 30031-30039. (IF: 6.696)
科研项目：
1.国家自然科学基金面上项目，30871390，雄激素受体AR介导基因转录调控的辅调节因子筛选及生物学功能分析，2009/01-2011/12，33万元，主持
2.国家自然科学基金面上项目，31171259，新因子hERAP调控ERa介导的基因转录及其在乳腺癌中的作用，2012/01-2015/12，60万元，主持
3. 973国家重大科学研究计划项目，2013CB945200，脂代谢紊乱与精子发生障碍的分子关联研究-血脂紊乱影响精子发生和成熟过程的关键基因的调控机制，2013/01-2017/12，133.5万元，研究骨干参与
4.国家自然科学基金面上项目，31271364，新因子hARAP3在AR介导基因转录调控及前列腺癌中的作用机制，2013/01-2016/12，80万元，主持
5.辽宁省高等学校优秀人才支持计划，LJQ2011086，CG1960在雄激素受体（AR）介导的基因转录调控及其在前列腺癌中的作用及机制研究，2011/10-2014/12，12万元，主持
6.教育部科学技术研究项目，213008a，新辅调节因子hARAP1在AR介导基因转录调控及前列腺癌中的作用及机制，2014/01-2016/12，50万元，主持
7.第五批辽宁省特聘教授基金 2016.1-2018.12，100万元，主持
8.国家自然科学基金面上项目，31871286，H3K4me3阅读子BAP18与ER形成正反馈调控机制及其乳腺癌生物学功能解析，2019/01-2022/12，60万元，主持
9.国家自然科学基金面上项目，32170603，组蛋白去泛素化酶MYSM1参与调控ERα信号通路的分子机制及其在乳腺癌中作用解析，2022/01-2025/12，58万元，主持
10.国家自然科学基金面上项目，32370634，组蛋白去甲基化酶UTX以酶非依赖方式上调AR活性在去势抵抗前列腺癌中的作用及机制研究，2024/01-2027/12，50万元，主持
荣誉表彰：
2013年03月 中国医科大学授予“三八红旗手”称号；
2015年10月 入选辽宁省特聘教授；
2016年06月 中共沈阳市委教科工作委员会授予“沈阳教科系统优秀共产党员”称号；
2016年10月 入选辽宁省百千万人才工程百层次；
2017年01月 中国医科大学授予“优秀科技工作者”称号；
2018年03月 入选沈阳市高层次人才；
2018年08月 国务院侨务办公室授予“全国归侨侨眷先进个人”称号；
2020年12月 中共辽宁省委教育工作委员会授予“辽宁省校园先锋示范岗”称号；
2020年12月 中国医科大学生命科学学院授予“优秀科技工作者”称号；
2021年03月 中国医科大学授予“优秀科技工作者”称号；
2021年05月 中共辽宁省委教育工作委员会拟授予“辽宁省高校优秀党务工作者”称号。
学会任职：
1.辽宁省生命科学学会放射学分会 副主任委员；
2.辽宁省生命科学学会肿瘤精准诊疗与临床转化分会 副主任委员
3.辽宁省生命科学学会 妇产科学分会 副主任委员
