个人简介:
刘莹 教授、硕博士生导师,主要研究方向:衰老分子生物学、基因治疗。
联系方式:liuying@cmu.edu.cn
研究成果:
1.Yangyang Zheng, Xin Xu, Ruoyue Fan, Haolang Jiang, Qingguo Guo, Xuefei Han, Ying Liu*, Guangzuo Luo*. Intravitreal Delivery of rAAV2-hSyn-hRS1 Results in Retinal Ganglion Cell-Specific Gene Expression and Retinal Improvement in the Rs1-KO Mouse.Hum Gene Ther. 2024 May;35(9-10):342-354. (中科院分区2区,IF4.2)
2.Xin Xu, Ni Han, Fangkun Zhao, Ruoyue Fan, Qingguo Guo, Xuefei Han, Ying Liu*, Guangzuo Luo*.Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration.Mol Ther Nucleic Acids.. 2024 Mar 25;35(2):102176.(中科院分区2区,IF8.8)
3.Yuan Meng, Haotian Liu, Haoran Zhu, Wanrong Zhang, Dong Sun, Xuefei Han, Ying Liu*, Guangzuo Luo*. RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment. J Immunother Cancer. 2024 Jan 11;12(1):e007171.(中科院分区1区,IF10.9)
4.Ni Han, Xin Xu, Ying Liu*, Guangzuo Luo*. AAV2-antiVEGFscFv gene therapy for retinal neovascularization.Mol Ther Methods Clin Dev. 2023 Oct 29:31:101145.(中科院分区2区,IF4.7)
5.Yuran Duan, Qingguo Guo, Tianrui Zhang, Yuan Meng, Dong Sun, Guangzuo Luo*, and Ying Liu*.Cyclin-dependent kinase–mediated phosphorylation of the exocyst subunit Exo84 in late G1 phase suppresses exocytic secretion and cell growth in yeast.J. Biol. Chem. (2019) 294(29) 11323–11332.(中科院分区2区,IF=4.106)
6.Ying Liu, Tianrui Zhang, Dong Sun and Guangzuo Luo*. The Cdc42 effectors Gic1 and Gic2 regulate polarized post‑Golgi secretion. Cell Biosci (2019) 9:33.(中科院分区3区,IF=5.026)
7. Qingguo Guo, Tianrui Zhang, Na Meng, Yuran Duan, Yuan Meng, Dong Sun, Ying Liu*and Guangzuo Luo*. Sphingolipids are required for exocyst polarity and exocytic secretion in Saccharomyces cerevisiae. Cell Biosci, 2020, 10:53.中科院分区2区,IF7.133)
8. Yuan Meng, Dong Sun, Yiyan Qin, Xiaoyi Dong, Guangzuo Luo*, Ying Liu*.Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system.Mol Ther Methods Clin Dev. 2021 Feb 27;21:28-41.(中科院分区2区,IF6.7)
9.Qingguo Guo, Na Meng, Guanzhi Fan, Dong Sun, Yuan Meng, Guangzuo Luo*, Ying Liu* .The role of the exocytic pathway in cell wall assembly in yeast. Yeast . 2021 Oct;38(10):566-578.(中科院分区3区,IF3.3)
10.Qingguo Guo, Yuran Duan, Na Meng, Ying Liu*,Guangzuo Luo*. The N-terminus of Sec3 is required for cell wall integrity in yeast. Biochimie. 177(2020):30-39.(中科院分区3区,IF4.1)
11.第七届中国国际“互联网+”大学生创新创业大赛三等奖(指导教师)。
科研项目:
1.国家自然基金面上项目,生长激素受体敲除通过肌肉因子Irisin分泌改善衰老伴发胰岛素抵抗的机制研究,课题经费55万元。项目期限:2021年1月-2024年12月,主持,在研。
2.国家自然基金面上项目,酵母细胞中鞘脂LCB调节mRNA降解机制的研究,课题经费:62万元。项目期限:2016年1月-2020年12月,主持,已结题;
3.辽宁省自然科学基金,Tor1/Ras2/Sch9通过actin动态化影响细胞时序寿命的研究,课题经费10万元。项目期限:2013年1月-2015年12月,主持,已结题;
4.辽宁省自然科学基金:蛋白激酶A在小鼠受精卵发育调控中的作用,课题经费4万元。项目期限:2005年1月-2007年12月,主持,已结题。