个人简介：

李渊，男，1988年生，副教授，硕士生导师，沈阳市高层次人才拔尖人才，中国医科大学高层次青年人才，现任发育细胞生物学教研室副主任。博士毕业于清华大学医学部-北京协和医学院，获生物化学与分子生物学博士学位。博士期间获“国家留学基金委-公派留学项目”支持，赴美国耶鲁大学、范德堡大学留学一年。曾以全球前200高校优秀博士毕业生身份，获辽宁省政府奖励。主要研究方向为“脑稳态维系与脑疾病演进的表观调控机制”，围绕该研究方向已主持国家自然科学基金面上项目、青年项目和辽宁省自然科学基金项目。目前作为第一作者/通讯作者（共同）在Cell Reports, J Cereb Blood Flow Metab等期刊发表研究论文4篇；参编外文学术专著1部。教学方面承担研究生、5+3一体化、五年制及生物技术专业本科生的理论课及实验课教学工作。

联系方式：liyuan@cmu.edu.cn

研究成果：

(1)Yuan Li; Jia-Yi Wei; Hui Liu; Kang-Ji Wang; Sheng-Nan Jin; Zheng-Kang Su; Hui-Jie Wang; Jun-Xiu Shi; Bo Li; De-Shu Shang; Wen-Gang Fang; Xiao-Xue Qin; Wei-Dong Zhao; Yu-Hua Chen ; An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity, Cell Reports, 2022, 39(2): 110656 (中科院一区期刊论文).

(2) Yun-Hua Zhao, Yu Liang, Kang-Ji Wang, Sheng-Nan Jin, Xiao-Meng Yu, Qian Zhang, Jia-Yi Wei, Hui Liu, Wen-Gang Fang, Wei-Dong Zhao,Yuan Li^*, Yu-Hua Chen^*. Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity. J Cereb Blood Flow Metab. 2024，271678X241248907(中科院二区期刊论文).

(3) Hui Liu; Jia-yi Wei;Yuan Li; Meng Ban; Qi Sun; Hui-Jie Wang; Dan Zhao; Pai-Ge Tong; Li Wang; Kang-Ji Wang; Jin-Li Yue; Hong-Yan Zhang; Wen-Gang Fang; Dong-Xin Liu; De-Shu Shang; Bo Li; Ya-Ping Jin; Liu Cao; Wei-Dong Zhao; Yu-Hua Chen ; Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier, J Cell Biol. 2023 May 1;222(5):e202103098. (中科院一区期刊论文).

(4) Shi-Yu Tang; Dong-Xin Liu;Yuan Li; Kang-Ji Wang; Xia-Fei Wang; Zheng-Kang Su; Wen-Gang Fang; Xiao-Xue Qin; Jia-Yi Wei; Wei-Dong Zhao; Yu-Hua Chen ; Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells, Frontiers in Molecular Neuroscience, 2020, 13: 23 (中科院二区期刊论文).

(5)Li, Yuan; Li, Yan; Huang, Shengkai; He, Kun; Zhao, Mei; Lin, Hong; Li, Dongdong; Qian, Jiaming; Zhou, Caihong; Chen, Yuhua; Huang, Changzhi ; Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expression., Oncotarget, 2017, 8(8): 13690-13702 (中科院二区期刊论文).

(6)Li, Yuan; Huang, Shengkai; Li, Yan; Zhang, Weilong; He, Kun; Zhao, Mei; Lin, Hong; Li, Dongdong; Zhang, Honggang; Zheng, Zhaoxu; Huang, Changzhi ; Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells., Tumor Biology, 2016, 37(10): 14205-14215 (中科院二区期刊论文).

(7)Li Yuan; Li Yan; Huang Changzhi ; Circulating miRNAs Incresaing the Risk of Cancer, ELSEVIER, ISBN:978-0-12-811022-5, 2017 (外文学术专著).

科研项目：

1.内皮细胞膜SNHG20-FABP5互作调控DHA脂肪酸跨血脑屏障转运促进神经血管单元损伤修复的机制，国自然面上项目，32371207，主持，50万，2024年01月至2027年12月；

2.SNHG12结合Occludin抑制其泛素化维系脑缺血应激损伤中血脑屏障结构稳态的研究，国自然青年项目，31900826，主持，24万，2020年01月至2022年12月。