王振宁 教授、主任医师
二级教授、博士生导师
现任中国医科大学党委书记、校长，胃肠肿瘤精准诊疗教育部重点实验室负责人，辽宁省胃肠肿瘤临床医学研究中心负责人，国家卫生计生突出贡献中青年专家，科技部创新人才推进计划中青年科技创新领军人才，国家百千万人才工程国家级人选，享受国务院政府特殊津贴。兼任中华医学会肿瘤学分会胃癌学组组长等职务。主持国家自然科学基金,包括国际（地区）合作与交流项目、联合基金及面上项目等，国家重点研发计划精准医学研究专项课题、973计划前期研究专项及其他省部级项目共20余项；在JAMA Oncology、Molecular Cancer、Science Advances、Nature Communications等国际期刊发表SCI论文281篇，其中第一作者或通讯作者159篇，获国家科技进步二等奖及省部级科技进步奖等多项奖项。
课题组主要成员
教 授： 苗智峰
教 授： 宋永喜
副教授： 高 鹏
教 授： 孙景旭
教 授： 赵俊华
副教授： 陈晓婉
科研方向
1.提出胃癌发生新理念，确定早诊新标志
2.探索腹膜转移新机制，提出防治新策略
3.阐明淋巴转移新途径，探寻治疗新靶点
4.研发新型抗癌药物，促进临床应用转化
5.人工智能数据挖掘，优化临床分期系统
6.搭建医工结合平台，促进学科交叉融合
学术贡献
1.To explain the regulation of energy metabolism on the differentiation and proliferation of gastric mucosal stem cells and the occurrence of gastric cancer.
2.To invent the new concept of "paligenosis" to define the process of fully differentiated cells reversely differentiate and gain proliferation ability, and firstly describe the pathological and molecular characteristics of paligenosis.
3.To report a non-coding RNA regulatory network for CLDN4 in gastric cancer and develop small molecule compounds according to this regulatory network.
4.To propose a series of optimization schemes for TNM staging, among which the optimized scheme for TNM staging of colorectal cancer was written into the 8th AJCC TNM staging guide.
5.To rapidly separate live gastric cancer cells from patients'ascites and achieved label-free characterization of gastric cancer cells by optically induced electrokinetics (OEK) based microfluidic method.
代表性论文
1.Huang XZ, Gao P, Wang ZN*. Antibiotic Treatment and Immune Checkpoint Inhibitor Therapy in Patients With Cancer. JAMA Oncol. 2020 Apr 1;6(4):586-587.
2.Miao ZF , Sun JX , Mahliyah Adkins-Threats , Min-Jiao Pang , Jun-Hua Zhao , Xin Wang , Kai-Wen Tang , Wang ZN*, Jason C Mills*. DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia. Gastroenterology. 2020 Sep 18;S0016-5085(20)35164-7.
3.Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z*, Song S*, Ajani JA*. LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma. Mol Cancer. 2019 Oct 10;18(1):141.
4.Zhang YZ, Zhao JH, Yu HB*, Li P, Liang WF, Liu Z, Gwo-Bin Lee, Liu LQ, Li WJ*, and Wang ZN*. Detection and isolation of free cancer cells from ascites and peritoneal lavages using optically induced electrokinetics (OEK). Sci Adv. 2020 Aug 5;6(32):eaba9628.
5.Song YX, Sun JX, Zhao JH, Yang YC, Shi JX, Wu ZH, Chen XW, Gao P, Miao ZF, Wang ZN*. Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. Nat Commun. 2017 Aug 18;8(1):289.
6.Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN*, Mills JC*. Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J. 2018 Apr 3;37(7). pii: e98311.
7.Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu JY, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN*, Mills JC*. A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle. DEV CELL. 2020 Oct 26;55(2):178-194.e7.
8.Miao ZF, Cho CJ, Wang ZN*, Mills JC*. Autophagy repurposes cells during paligenosis. Autophagy. 2020 Dec 7;1-2.
9.Ge ZX , Zhao JH , Yu HB, Yang WG, Zhou PL, Wang*, Liu LQ*. Biomimetic construction of peritoneum to imitate peritoneal metastasis using digital micromirror device-based optical projection lithography. Lab Chip. 2020 Aug 26;20(17):3109-3119.
10.Tong LL, Gao P, Wang ZN*, Song YX, Xu YY, Sun Z, Xing CZ, Xu HM. Is the seventh edition of the UICC/AJCC TNM staging system reasonable for patients with tumor deposits in colorectal cancer? Ann Surg. 2012 Feb; 255(2):208-13.
11.Song Y, Xu Y, Wang Z*, Chen Y, Yue Z, Gao P, Xing C, Xu H. MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer. Int J Cancer. 2012 Sep 1; 131(5): 1042-51.
12.Li Y, Song SM, Pizzi MP, Han HY, Scott AW, Jin JK, Xu Y, Wang Y, Huo LF, Ma L, Vellano C, Luo XL, MacLeod R, Wang LH, Wang ZN*, Ajani JA. LncRNA PVT1 Is a Poor Prognosticator and Can Be Targeted by PVT1 Antisense Oligos in Gastric Adenocarcinoma. Cancers (Basel). 2020 Oct 15;12(10):2995.
13.Chen Y, Song YX, Wang ZN*. The MicroRNA-148/152 Family: Multi-faceted Players. Mol Cancer. 2013 May 19; 12: 43.
14.Song YX, Yue ZY, Wang ZN*, Xu YY, Luo Y, Xu HM, Zhang X, Jiang L, Xing CZ, Zhang Y. MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer. 2011 Jan 4; 10: 1.
