刘慧鑫 教授

博士生导师  沈阳市“领军人才”

    刘慧鑫教授分别于2001年在哈尔滨工业大学获得学士学位和2010年在中国科学院大连化学物理研究所获得博士学位。博士毕业后，赴美继续进行科学研究工作，具有十年海外工作经历。于2019年择优获选中国医科大学“青年拔尖人才”项目，入职生命科学学院筹建消化道生理研究室，并担任主任。于2020年获聘健康科学研究院独立PI，建立“肥胖与代谢性疾病课题组”并担任首席科学家。 刘慧鑫教授利用其交叉学科研究背景，采用基因组学、代谢物组学、生物信息学等研究方法手段在其主要研究方向-肝病学领域进行了大量的工作，并率先开展肠道菌群与肝脏损伤修复再生的关系研究，取得了一系列研究成果，所发表在肝病学权威杂志Journal of Hepatology上的文章已被引用近百次，并得到科学界和公共媒体的广泛关注及报道，为肝脏再生研究提供了新的研究思路。目前已经发表四十余篇SCI收录文章，H-index 24。

课题组成员
课题组PI：  刘慧鑫
科研骨干：  荀哲
高级实验师：葛鑫
博士研究生：赵珊珊 吴振华 王笑宇 陈磊
硕士研究生：杨静 金至皓 原文政

科研方向

团队致力于肥胖与代谢性相关疾病的基础和医学转化研究。充分利用交叉学科研究背景，结合在肝病学、多组学研究、生物信息学、以及抗肿瘤纳米药物等领域的研究积累，围绕肠-肝轴在肝脏损伤及再生、癌症发生及发展、以及调节能量平衡和糖/脂代谢防治肥胖及代谢性疾病等方面的关键作用展开深入研究。
肠-肝轴在肝脏损伤及再生修复中的作用机理
肠-肝轴调节能量平衡和糖/脂代谢防治肥胖及代谢性疾病
抗肿瘤纳米药物的研制及作用机理

主要学术贡献

Nuclear Receptor-regulated hepatic metabolism and liver regeneration
The interaction of gut-derived signaling and nuclear receptors in liver and colon cancer
Gut-liver axis signaling in regulating metabolism-driven cell proliferation as well as cell death
The role of Traditional Chinese Medicine in liver biology and liver cancer

代表性论文
Sheng L, Jena PK, Hui-Xin Liu, Hu Y, Nagar N, Bronner DN, Settles ML, Bäumler AJ, Wan YY. Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila. FASEB J. 2018 Jun 8:fj201800370R. doi: 10.1096/fj.201800370R.
Lili Sheng, Prasant K. Jena, Ying Hu, Hui-Xin Liu, Nidhi Nagar, Karen M. Kalanetra, Samuel William French, Samuel Wheeler French, David A. Mills, Yu-Jui Yvonne Wan. Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation. The Journal of Pathology. 2017, 243(4):431-441.
Prasant K. Jena, Lili Sheng, Hui-Xin Liu, Karen M. Kalanetra, Annie Mirsoian, William J. Murphy, Samuel W. French, Viswanathan V. Krishnan, David A. Mills, Yu-Jui Yvonne Wan. Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment. Am J Pathol. 2017,187(8):1800-1813.
Lili Sheng, Prasant K. Jena, Hui-Xin Liu, Karen M. Kalanetra, Frank J. Gonzalez, Samuel W. French, Viswanathan V. Krishnan, David A. Mills, Yu-Jui Yvonne Wan. Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. Sci Rep. 2017, 11;7(1):1748.
Hui-Xin Liu, Clarissa Santos Rocha, Satya Dandekar, Yu-Jui Yvonne Wan. Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration. Journal of Hepatology. 2016, 64(3):641-50.
Hui-Xin Liu, Ying Hu, Yu-Jui Yvonne Wan. Microbiota and Bile Acid Profiles in Retinoic Acid-primed Mice that Exhibit Accelerated Liver Regeneration. Oncotarget. 2016, 7(2):1096-106.
Hui-Xin Liu, Ryan Keane, Lili Sheng, Yu-Jui Yvonne Wan. Implications of microbiota and bile acid in liver injury and regeneration. Journal of Hepatology. 2015, 63(6):1502-10.
Hui-Xin Liu, Ying Hu, Samuel French, Frank Gonzalez, Yu-Jui Yvonne Wan. Forced Expression of Fibroblast Growth Factor 21 Reverses the Sustained Impairment of Liver Regeneration in hPPARαPAC Mice due to Dysregulated Bile Acid Synthesis. Oncotarget. 2015, 30;6(12):9686-9700.
Fan Yang, Ying Hu, Hui-Xin Liu, Yu-Jui Yvonne Wan. MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. The Journal of Biological Chemistry. 2015, pii: jbc.M114.620369.
Ying Hu, Thinh Chau, Hui-Xin Liu, Degui Liao, Ryan Keane, Yuqiang Nie, Hui Yang, Yu-Jui Yvonne Wan. Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis. Molecular Cancer Research. 2014, pii: molcanres.0230.2014.
Fan Yang, Yuqi He, Hui-Xin Liu, Jessica Tsuei, Xiaoyue Jiang, Li Yang, Zheng-Tao Wang, Yu-Jui Yvonne Wan. All-trans retinoic acid regulates hepatic bile acid homeostasis. Biochemical Pharmacology. 2014, 15;91(4):483-9.
Ying Hu, Qi Zhan, Hui-Xin Liu, Thinh Chau, Yuyuan Li, Yu-Jui Yvonne Wan. Accelerated partial hepatectomy-induced liver cell proliferation is associated with liver injury in Nur77 knockout mice. The American Journal of Pathology. 2014, doi: 10.1016/j.ajpath.2014.08.002.
Hui-Xin Liu, Irene Ly, Ying Hu, Yu-Jui Yvonne Wan. Retinoic acid regulates cell cycle genes and accelerates normal mouse liver regeneration. Biochemical Pharmacology. 2014, 91:256-265.
Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-Bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo. Genome-wide binding and transcriptome analysis of human farnesoid x receptor in primary human hepatocytes. PLOS One. 2014, 9:e105930.
Ying Hu, Hui-Xin Liu, Yuqi He, Yaping Fang, Jianwen Fang, Yu-Jui Yvonne Wan. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Biochemical Pharmacology. 2013, 85:1007-1017.
Hui-Xin Liu, Yaping Fang, Ying Hu, Frank J. Gonzalez, Jianwen Fang, Yu-Jui Yvonne Wan. PPARβ regulates liver regeneration by modulating Akt and E2f signaling. PLOS One. 2013, 8:e65644.
Yaping Fang, Hui-Xin Liu, Ning Zhang, Grace L. Guo, Yu-Jui Yvonne Wan, Jianwen Fang. NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse. Bioinformatics. 2013, 29:295-297.
Ao-Xue Wang, Ying Hu, Hui-Xin Liu*, Xiao-Yi Qi, Yong Liu, Cai-Xia Tu, Ling Yang. C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica. 2011, 41:349-357.